Vein graft failure.
Vein graft failure.
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DOI：
10.1016/j.jvs.2013.08.019
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发表时间：
2015-01
影响因子：
4.3
通讯作者：
Conte, Michael S.
中科院分区：
文献类型：
--
作者：
Owens, Christopher D.;Gasper, Warren J.;Rahman, Amreen S.;Conte, Michael S.
在建立了自体静脉搭桥术后，静脉必须经历一系列动态结构变化以稳定动脉血流动力。这些变化，通常被称为重塑，包括炎症反应，新生内膜的发展，基质的更新，以及细胞的增殖和凋亡。这些过程的总和导致动脉化静脉的物理和生物力学属性发生戏剧性的变化。临床上最明显和最容易测量的是移植物的管腔重塑。然而，尽管不太精确，但在愈合的静脉移植物中，可以在体内测量壁厚、基质成分和内皮细胞的变化。最近的翻译工作已经证明了重塑的临床相关性，因为它与静脉移植物的通畅性和影响它的系统因素有关。通过将静脉中的组织学和分子变化联系起来，对预防搭桥失败的潜在治疗策略和未来研究的领域进行了深入的探索。
Following the creation of an autogenous lower extremity bypass graft, the vein must undergo a series of dynamic structural changes to stabilize the arterial hemodynamic forces. These changes, commonly referred to as remodeling, include an inflammatory response, the development of a neointima, matrix turnover, and cellular proliferation and apoptosis. The sum total of these processes results in dramatic alterations in the physical and biomechanical attributes of the arterialized vein. The most clinically obvious and easily measured of these is lumen remodeling of the graft. However, though somewhat less precise, wall thickness, matrix composition, and endothelial changes can be measured in vivo within the healing vein graft. Recent translational work has demonstrated the clinical relevance of remodeling as it relates to vein graft patency and the systemic factors influencing it. By correlating histologic and molecular changes in the vein, insights into potential therapeutic strategies to prevent bypass failure and areas for future investigation are explored.
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影响因子：
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