Second acute leukemia and other malignancies following treatment for Hodgkin's disease.
Second acute leukemia and other malignancies following treatment for Hodgkin's disease.
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霍奇金病治疗后的第二次急性白血病和其他恶性肿瘤。
DOI：
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发表时间：
1986
影响因子：
45.3
通讯作者：
G. Bonadonna
中科院分区：
文献类型：
--
作者：
P. Valagussa;A. Santoro;F. Fossati‐Bellani;A. Banfi;G. Bonadonna
本文分析了1965年至1982年收治的1，329例何杰金氏病患者的记录，以评估继发肿瘤的相对频率。在平均9.5年的随访中，共记录了68例新癌症。19例急性非淋巴细胞白血病，6例非霍奇金淋巴瘤，43例不同类型的实体瘤被确定。非霍奇金淋巴瘤的总体风险为1.3% +/- 0.6%，实体瘤的总体风险为8.3% +/- 1.5%（包括基底细胞癌）和6.7% +/- 1.4%（排除基底细胞癌）。仅接受放射治疗的患者中未记录白血病病例。12年白血病治疗估计值如下：化疗仅为1.4% +/- 2.3%;放疗加MOPP（氮芥、长春新碱、甲基苄肼和泼尼松）10.2% +/- 5.2%;放疗加ABVD（阿霉素、博莱霉素、长春碱和达卡巴嗪）0;放疗加其他药物方案4.8% +/-1.6%。在放疗失败后接受补救性MOPP的患者中，白血病的风险特别高（15.5% ± 7.4%）。年龄增加与继发恶性肿瘤，尤其是白血病的风险之间也存在正相关。从潜在的治愈性治疗中删除某些药物，如烷化剂、丙卡巴肼和亚硝基脲衍生物，可以显著降低继发性肿瘤的发生率。
The records of 1,329 patients with Hodgkin's disease admitted from 1965 to 1982 were analyzed to assess the relative frequency of second neoplasms. Within a median follow-up of 9.5 years, a total of 68 new cancers were documented. Nineteen cases of acute nonlymphocytic leukemia, 6 cases of non-Hodgkin's lymphomas, and 43 cases with different types of solid tumors were identified. The overall risk of non-Hodgkin's lymphoma was 1.3% +/- 0.6% and of solid tumors was 8.3% +/- 1.5% when basal cell carcinomas were included and 6.7% +/- 1.4% when basal cell carcinomas were excluded. No cases of leukemia were documented in patients treated with radiation therapy only. The 12-year estimate of leukemia by treatment was as follows: chemotherapy only 1.4% +/- 2.3%; radiation plus MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) 10.2% +/- 5.2%; radiation plus ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine) 0; and radiation plus other drug regimens 4.8% +/- 1.6%. The risk of leukemia was particularly high (15.5% +/- 7.4%) in patients who received salvage MOPP after radiation failure. A positive association was also noted between increasing age and risk of second malignancies, especially leukemia. The incidence of second neoplasms can be markedly decreased by deleting from potentially curative therapy certain drugs such as alkylating agents, procarbazine, and nitrosourea derivatives.
阿糖胞苷治疗继发性急性非淋巴细胞白血病。
DOI：
10.1056/nejm198301063080105
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
Preisler,HD;Early,AP;Raza,A;Vlahides,G;Marinello,MJ;Stein,AM;Browman,G
通讯作者：
Browman,G
霍奇金病并发的第二种恶性肿瘤：西南肿瘤学组 10 年随访。
DOI：
--
发表时间：
1982
期刊：
Cancer treatment reports
影响因子：
--
作者：
ColtmanJr,CA;Dixon,DO
通讯作者：
Dixon,DO
霍奇金病成功治疗患者的第二种恶性肿瘤：癌症和白血病 B 组研究。
DOI：
--
发表时间：
1982
期刊：
Cancer treatment reports
影响因子：
--
作者：
Glicksman,AS;Pajak,TF;Gottlieb,A;Nissen,N;Stutzman,L;Cooper,MR
通讯作者：
Cooper,MR