Triglyceride-Glucose Index and Intravenous Thrombolysis Outcomes for Acute Ischemic Stroke: A Multicenter Prospective-Cohort Study.
Triglyceride-Glucose Index and Intravenous Thrombolysis Outcomes for Acute Ischemic Stroke: A Multicenter Prospective-Cohort Study.
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DOI：
10.3389/fneur.2022.737441
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发表时间：
2022
影响因子：
3.4
通讯作者：
Chao AC
中科院分区：
文献类型：
--
作者：
Lin SF;Hu HH;Chao HL;Ho BL;Chen CH;Chan L;Lin HJ;Sun Y;Lin YY;Chen PL;Lin SK;Wei CY;Lin YT;Lee JT;Chao AC
甘油三酯-葡萄糖（TyG）指数最近被提议作为胰岛素抵抗的可靠标志。没有足够的证据证明 TyG 指数与功能结果和出血转化以及接受静脉溶栓 (IVT) 治疗的中风患者相关。我们设计了一项多中心队列研究，纳入 2004 年 12 月至 2016 年 12 月期间接受 IVT 治疗的急性缺血性卒中患者。TyG 指数分为三分位数并按连续量表计算。不良功能结果通过 90 天的改良 Rankin 量表 3-6 进行定义，并调查了 IVT 发作 36 小时内症状性颅内出血 (SICH) 的发生率。根据美国国立卫生研究院中风量表 (NIHSS) 评分，中风严重程度被定义为轻度 (4-8)、中度 (9-15) 或高 (≥16)。在 914 名入组患者中，T1 的 TyG 指数三分位数为 8.48，T2 为 8.48-9.04，T3 为 9.04。 T3 显示 90 天时出现不良功能结果的风险增加[比值比 (OR)：1.76； P = 0.0132]。 TyG 指数与 90 天时的不良功能结果显着相关（OR：1.32；每增加单位 P = 0.0431）。未发现 TyG 指数与 SICH 之间存在关联。这些发现适用于T3期中度卒中（OR，2.35；P=0.0465）和高度严重性（OR：2.57，P=0.0440）卒中患者。这项研究支持了接受 IVT 治疗的急性缺血性中风患者 90 天时 TyG 指数增加与不良功能结果增加之间的密切相关性。这些发现对于中度和高度中风严重程度的患者来说是有效的。
The triglyceride-glucose (TyG) index has recently been proposed as a reliable marker of insulin resistance. There is insufficient evidence to verify that the TyG index is correlated with functional outcomes and hemorrhagic transformation and in patients with stroke treated with intravenous thrombolysis (IVT). We designed a multicenter cohort study, which enrolled patients with acute ischemic stroke treated with IVT between December 2004 and December 2016. The TyG index was divided into tertiles and calculated on a continuous scale. Unfavorable functional outcomes were defined by the modified Rankin Scale of 3–6 at 90 days and the incident rates of symptomatic intracranial hemorrhage (SICH) within 36 h of IVT onset were surveyed. Stroke severity was defined as mild (4–8), moderate (9–15), or high (≥16) based on the National Institutes of Health Stroke Scale (NIHSS) scores. Among 914 enrolled patients, the tertiles of the TyG index were 8.48 for T1, 8.48–9.04 for T2, and 9.04 for T3. T3 showed an increased risk of unfavorable functional outcomes at 90 days [odds ratio (OR): 1.76; P = 0.0132]. The TyG index was significantly associated with unfavorable functional outcomes at 90 days (OR: 1.32; P = 0.0431 per unit increase). No association was found between the TyG index and SICH. These findings were applicable for T3 with stroke of moderate (OR, 2.35; P = 0.0465) and high severity (OR: 2.57, P = 0.0440) patients with stroke. This study supports the strong association between the increased TyG index and increased unfavorable functional outcomes at 90 days in patients with acute ischemic stroke treated with IVT. These findings were found to be robust in patients with moderate and high stroke severity.
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影响因子：
1.4
作者：
Locateli, Joao Carlos;Lopes, Wendell Arthur;Nardo Junior, Nelson
通讯作者：
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影响因子：
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影响因子：
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作者：
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