Platelet Calcium‐Linked Abnormalities in Essential Hypertension a
Platelet Calcium‐Linked Abnormalities in Essential Hypertension a
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原发性高血压患者的血小板钙相关异常
DOI：
--
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发表时间：
1986
影响因子：
5.2
通讯作者：
F. Bühler
中科院分区：
文献类型：
--
作者：
T. Resink;Dimitar Dimitrov;A. Zschauer;P. Erne;V. Tkachuk;F. Bühler
胞浆内钙离子的变化在许多基础和临床重要的(病理)生理过程中提供了关键环节。细胞外[Ca“]大约是细胞内[Ca~(2+)]的5,000-10,000倍，但由于质膜对Ca~(2+)的低通透性，Ca~(2+)的进入依赖于电压依赖和/或受体操作的钙通道开放。细胞内钙离子储存室由质膜、内质网、线粒体和胞浆钙结合蛋白组成。虽然钙离子内流在细胞激活中起重要作用，但胞浆内游离钙离子的增加也依赖于内质网和/或质膜中钙离子的释放。有一些控制系统可以维持钙离子的动态平衡。质膜上的Ca~(2+)浓度梯度需要依赖能量的过程来挤出Ca~(2+)：依赖于钙调素的Ca~(2+)-ATPase和Na~+/Ca~(2+)交换系统的作用，使Na~+沿其浓度梯度向下流入，驱动Ca~(2+)向其浓度梯度外流。后者的运行依赖于Na+/K+ATPase泵，它的功能是维持N a f浓度梯度。钙离子也通过依赖于ATP的摄取进入内质网和线粒体而从胞浆中隔离出来，尽管线粒体只有在胞浆中的钙浓度高于2.0 pm时才成为重要的钙离子转运体。这些系统并行工作，在不同的细胞中具有不同的相对亲和力。它们的作用由它们特定的动力学性质决定。例如，质膜和内质网是高亲和力/低容量系统，而线粒体1钙摄取和Na+/钙+交换是低亲和力/高容量系统。
Changes in cytoplasmic Ca2+ ( [Ca2+li) provide pivotal links in many fundamental and clinically important (patho-)physiological processes. A simple generalized representation of cellular Ca2+ compartmentalization and flux systems is given in FIGURE 1. Extracellular [Ca" ] is approximately 5,000-10,000 times greater than intracellular [Ca2+], but due to the low permeability of plasma membranes for Ca2+, the entry of Ca2+ depends on calcium channel openings, voltage dependent and/or receptor operated. Cellular Ca2+ storage compartments comprise the plasma membrane, endoplasmic reticulum, mitochondria, and cytosolic Ca2+ binding proteins. Although Ca2+ influx is important in cell activation, the increase in cytoplasmic free Ca2+ is also dependent on release of Ca2+ from the endoplasmic reticulum and/or plasma membrane. There are control systems that maintain Ca2+ homeostasis. The Ca2+ concentration gradient across the plasma membrane necessitates Caz+ extrusion by energydependent processes: the action of a calmodulin-dependent Ca2+ ATPase and a Na+/Ca2+ exchange system whereby influx of N a + down its concentration gradient drives Ca2+ efflux against its concentration gradient. The operation of the latter is dependent on the N a + / K + ATPase pump, which functions to maintain the N a f concentration gradient. Ca2+ is also sequestered from the cytosol via ATP-dependent uptake into the endoplasmic reticulum and mitochondria, although mitochondria only become significant Ca2+ transporters when cytosolic Ca2+ rises above 2.0 pM. These systems work in parallel and with different relative affinities in different cells. Their roles are dictated by their specific kinetic properties. For example, the plasma membrane and endoplasmic reticulum are high affinity/low capacity systems, whereas mitochondria1 Ca2+ uptake and Na+/Ca2+ exchange are low affinity/high capacity systems.'d
磷脂酰肌醇 4,5-二磷酸可能代表刺激人血小板后质膜结合钙的释放位点。
DOI：
10.1016/0006-291x(84)91437-2
发表时间：
1984
影响因子：
3.1
作者：
Broekman,MJ
通讯作者：
Broekman,MJ
佛波酯受体：一种磷脂调节的蛋白激酶。
DOI：
10.1016/0304-4157(85)90009-7
发表时间：
1985
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Ashendel,CL
通讯作者：
Ashendel,CL