Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral Pain.
Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral Pain.
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DOI：
10.3389/fphys.2017.01040
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发表时间：
2017
影响因子：
4
通讯作者：
Braidy N
中科院分区：
文献类型：
--
作者：
Nazıroğlu M;Braidy N
异常的Ca 2+通道生理学、表达水平和对热的超敏反应与化疗药物治疗后的几种疼痛状态有关。作为Ca ~（2+）渗透性瞬时受体电位（TRP）的成员，其中5个通道（TRPV 1 -4和TRPM 2）被不同的热温度激活，其中2个通道（TRPA 1和TRPM 8）被冷温度激活。越来越多的证据表明，TRPA 1和TRPM 8的拮抗剂可以保护顺铂，奥沙利铂和紫杉醇诱导的线粒体氧化应激，炎症，冷异常性疼痛和痛觉过敏。TRPV 1参与顺铂诱导的感觉神经元热痛敏和机械痛敏。TRPA 1，TRPM 8和TRPV 2蛋白表达水平主要增加背根（DRG）和三叉神经节，这些治疗。关于DRG中直接或奥沙利铂诱导的氧化冷应激依赖性TRPA 1和TRPV 4激活存在争议。参与的分子途径，如半胱氨酸基团，谷胱甘肽代谢，花生四烯酸，cAMP，脂多糖，蛋白酶激活受体2，和丝裂原活化蛋白激酶也表明在奥沙利铂和紫杉醇诱导的冷异常性疼痛。本文综述了5种温度调节TRP通道（TRPA 1、TRPM 8、TRPV 1、TRPV 2和TRPV 4）作为治疗化疗引起的外周疼痛的新靶点的研究结果
Abnormal Ca2+ channel physiology, expression levels, and hypersensitivity to heat have been implicated in several pain states following treatment with chemotherapeutic agents. As members of the Ca2+ permeable transient receptor potential (TRP), five of the channels (TRPV1-4 and TRPM2) are activated by different heat temperatures, and two of the channels (TRPA1 and TRPM8) are activated by cold temperature. Accumulating evidences indicates that antagonists of TRPA1 and TRPM8 may protect against cisplatin, oxaliplatin, and paclitaxel-induced mitochondrial oxidative stress, inflammation, cold allodynia, and hyperalgesia. TRPV1 was responsible from the cisplatin-induced heat hyperalgesia and mechanical allodynia in the sensory neurons. TRPA1, TRPM8, and TRPV2 protein expression levels were mostly increased in the dorsal root (DRG) and trigeminal ganglia by these treatments. There is a debate on direct or oxaliplatin-induced oxidative cold stress dependent TRPA1 and TRPV4 activation in the DRG. Involvement of molecular pathways such as cysteine groups, glutathione metabolism, anandamide, cAMP, lipopolysaccharide, proteinase-activated receptor 2, and mitogen-activated protein kinase were also indicated in the oxaliplatin and paclitaxel-induced cold allodynia. In this review, we summarized results of five temperature-regulated TRP channels (TRPA1, TRPM8, TRPV1, TRPV2, and TRPV4) as novel targets for treating chemotherapy-induced peripheral pain
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影响因子：
16.6
作者：
Chen, Jun;Kang, Dawon;Xu, Jing;Lake, Marc;Hogan, James O.;Sun, Chaohong;Walter, Karl;Yao, Betty;Kim, Donghee
通讯作者：
Kim, Donghee
DOI：
10.1523/jneurosci.5369-07.2008
发表时间：
2008-03-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andersson DA;Gentry C;Moss S;Bevan S
通讯作者：
Bevan S
DOI：
10.1073/pnas.0902675106
发表时间：
2009-11-24
影响因子：
11.1
作者：
Chuang, Huai-hu;Lin, Stephanie
通讯作者：
Lin, Stephanie
影响因子：
5.3
作者：
Dzagnidze, Anna;Katsarava, Zaza;Thomale, Juergen
通讯作者：
Thomale, Juergen
影响因子：
3.8
作者：
DEKONING, P;NEIJT, JP;GISPEN, WH
通讯作者：
GISPEN, WH