Preclinical progenitor cell therapy in traumatic brain injury: a meta-analysis.
Preclinical progenitor cell therapy in traumatic brain injury: a meta-analysis.
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DOI：
10.1016/j.jss.2017.02.078
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发表时间：
2017-06-15
期刊：
影响因子：
--
通讯作者：
Cox CS Jr
中科院分区：
文献类型：
--
作者：
Jackson ML;Srivastava AK;Cox CS Jr
没有治疗可用于逆转与创伤性脑损伤（TBI）相关的损伤。祖细胞疗法在临床前和临床研究中都显示出希望。我们对使用祖细胞治疗TBI的临床前研究进行了荟萃分析。使用预先指定的检索策略，在EMBASE、MEDLINE、科克伦综述、Biosis和Google Scholar中检索文章。对符合纳入标准的研究进行数据提取。根据固定效应模型，使用Review Manager 5.3进行分析，所有研究均进行质量评分。在识别的430篇摘要中，38篇符合纳入标准并进行了分析。平均质量得分为4.32分（满分8分）。没有一项研究获得了满分。病变体积（LV）和神经系统严重程度评分（NSS）结果支持细胞治疗，标准平均差（SMD）分别为0.86（95%CI 0.64，1.09）和1.36（95%CI 1.11，1.60）。Rotarod（RR）和Morris水迷宫（MWM）的结果也有利于治疗，SMD分别改善0.34（95%CI 0.02，0.65）和0.46（95%CI 0.17，74）。虽然LV和NSS对发表偏倚评估具有稳健性，但RR和MWM不具有稳健性。分析中的异质性（I2）范围为74%至85%，表明研究间存在大量异质性。作为质量分数函数的精密度显示，随着质量的提高，置信区间的大小在统计学上显著增加。我们的荟萃分析研究揭示了祖细胞治疗对LV和NSS的总体积极作用，在不同的TBI动物模型中有改善运动功能和空间学习的趋势。
No treatment is available to reverse injury associated with traumatic brain injury (TBI). Progenitor cell therapies show promise in both pre-clinical and clinical studies. We conducted a meta-analysis of pre-clinical studies using progenitor cells to treat TBI. EMBASE, MEDLINE, Cochrane Review, Biosis, and Google Scholar were searched for articles using pre-specified search strategies. Studies meeting inclusion criteria underwent data extraction. Analysis was performed using Review Manager 5.3 according to a fixed-effects model, and all studies underwent quality scoring. Of 430 abstracts identified, 38 met inclusion criteria and underwent analysis. Average quality score was 4.32 out of 8 possible points. No study achieved a perfect score. Lesion volume (LV) and Neurologic Severity Score (NSS) outcomes favored cell treatment with standard mean difference (SMD) of 0.86 (95%CI 0.64, 1.09) and 1.36 (95%CI 1.11, 1.60) respectively. Rotarod (RR) and Morris Water Maze (MWM) outcomes also favored treatment with improvements in SMD of 0.34 (95%CI 0.02, 0.65) and 0.46 (95%CI 0.17, 74) respectively. While LV and NSS were robust to publication bias assessments, RR and MWM were not. Heterogeneity (I2) ranged from 74% to 85% among the analyses, indicating a high amount of heterogeneity among studies. Precision as a function of quality score showed a statistically significant increase in the size of the confidence interval as quality improved. Our meta-analysis study reveals an overall positive effect of progenitor cell therapies on LV and NSS with a trend towards improved motor function and spatial learning in different TBI animal models.
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影响因子：
5.3
作者：
Chang, Janessa;Phelan, Michael;Cummings, Brian J.
通讯作者：
Cummings, Brian J.
影响因子：
6.1
作者：
Jiang J;Bu X;Liu M;Cheng P
通讯作者：
Cheng P
影响因子：
6
作者：
Bedi, Supinder S.;Hetz, Robert;Cox, Charles S., Jr.
通讯作者：
Cox, Charles S., Jr.
沃顿商学院的果冻移植改善了创伤性脑损伤大鼠模型的神经功能
影响因子：
4
作者：
Cheng, Tian;Yang, Bo;Li, Dongpeng;Ma, Shanshan;Tian, Yi;Qu, Ruina;Zhang, Wenjin;Zhang, Yanting;Hu, Kai;Guan, Fangxia;Wang, Jian
通讯作者：
Wang, Jian
影响因子：
8.3
作者：
Fisher M;Feuerstein G;Howells DW;Hurn PD;Kent TA;Savitz SI;Lo EH;STAIR Group
通讯作者：
STAIR Group