Adiponectin: A biomarker for chronic hepatitis C?

Adiponectin: A biomarker for chronic hepatitis C?
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脂联素:慢性丙型肝炎的生物标志物?

DOI:
10.1016/j.cyto.2015.10.016
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发表时间:
2017
期刊:
影响因子:
3.8
通讯作者:
Zhihong Li
Zhihong Li
中科院分区:
医学3区
文献类型:
--
作者:
Ding Liu;Shengyu Li;Zhihong Li

文献摘要

参考文献

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脂联素是一种主要由脂肪组织合成和分泌的激素,在脂质代谢中起着关键作用。慢性丙型肝炎(CHC)感染的特征是脂代谢紊乱,一段时间后可能演变为脂肪变性。越来越多的证据似乎将血浆脂联素水平降低与严重的CHC相关脂肪变性联系在一起,这表明这种脂肪因子作为临床应用的诊断和治疗靶点具有潜在的作用。在这篇综述中,我们试图总结脂联素在CHC中的研究现状,主要集中在它在CHC中的作用,以及它作为CHC生物标志物的潜在相关性。
Adiponectin, a hormone primarily synthesized and secreted by adipose tissue, plays a pivotal role in lipid metabolism. Chronic hepatitis C (CHC) infection is characterized by disordered lipid metabolism, which may potentially evolve into steatosis over a period of time. A growing body of evidence appears to link decreased adiponectin plasma levels with severe CHC-related steatosis, which suggests a potential role of this adipokine as a diagnostic and therapeutic target for clinical application. In this review, we have attempted to summarize the current status of adiponectin research in the context of CHC, concentrating predominantly on its roles in CHC, and its potential relevance as a biomarker for CHC.
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