Antibody to hepatitis B core antigen as a paradoxical marker for non-A, non-B hepatitis agents in donated blood.
Antibody to hepatitis B core antigen as a paradoxical marker for non-A, non-B hepatitis agents in donated blood.
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乙型肝炎核心抗原抗体作为捐献血液中非甲型、非乙型肝炎病原体的矛盾标记。
DOI：
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发表时间：
1986
影响因子：
39.2
通讯作者：
H. Alter
中科院分区：
文献类型：
--
作者：
D. Koziol;P. Holland;D. Alling;J. Melpolder;R. Solomon;R. Purcell;L. M. Hudson;F. Shoup;H. Krakauer;H. Alter
研究人员对 6293 名献血者和 481 名受血者进行了为期 6 至 9 个月的输血后随访，研究了供血者血液中乙型肝炎核心抗原（抗 HBc）抗体的存在与该血液受者发生肝炎之间的关系。在 193 名至少 1 单位抗 HBc 阳性血液接受者中，23 人 (11.9%) 发展为非甲非乙型肝炎，而 288 名仅接受抗 HBc 阴性血液的接受者中有 12 人 (4.2%) 发展为非甲型、非乙型肝炎（p 小于 0.001）。供体抗 HBc 状态与受者乙型肝炎的发生没有显着相关，与巨细胞病毒肝炎的发生呈负相关。供体抗 HBc 状态与受者发生非甲型、非乙型肝炎的关系与输血量和供体转氨酶水平升高无关。尽管 88% 的抗 HBc 阳性血液单位与受者非甲型、非乙型肝炎无关，但最大校正功效的计算预测，排除抗 HBc 阳性供者可能会预防 43% 的非甲型、非乙型肝炎病例，而供者损失为 4%。由于非甲非乙型肝炎会造成严重的慢性后果，因此必须认真考虑对非甲非乙型病毒携带者进行替代检测。
The relationship between the presence of antibody to hepatitis B core antigen (anti-HBc) in donor blood and the development of hepatitis in recipients of that blood was studied in 6293 blood donors and 481 recipients who were followed for 6 to 9 months after transfusion. Of 193 recipients of at least 1 unit of blood positive for anti-HBc, 23 (11.9%) developed non-A, non-B hepatitis compared with 12 (4.2%) of 288 recipients of only anti-HBc-negative blood (p less than 0.001). Donor anti-HBc status was not significantly associated with the development of hepatitis B in the recipient and was negatively associated with the development of cytomegalovirus hepatitis. The relationship of donor anti-HBc status and the development of non-A, non-B hepatitis in the recipient was independent of transfusion volume and elevated donor transaminase level. Although 88% of anti-HBc-positive blood units were not associated with recipient non-A, non-B hepatitis, calculation of maximal corrected efficacy predicted that exclusion of anti-HBc-positive donors might have prevented 43% of the cases of non-A, non-B hepatitis with a donor loss of 4%. Because of the serious chronic consequences of non-A, non-B hepatitis, surrogate tests for non-A, non-B virus carriers must be seriously considered.
非甲、非乙型输血后肝炎的长期病程。
影响因子：
29.4
作者：
Koretz,RL;Stone,O;Gitnick,GL
通讯作者：
Gitnick,GL
影响因子：
158.5
作者：
BRECHOT, C;DEGOS, F;BERTHELOT, P
通讯作者：
BERTHELOT, P