In Vivo Monitoring of Circadian Output in Clock Mutant Mice

In Vivo Monitoring of Circadian Output in Clock Mutant Mice
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时钟突变小鼠昼夜节律输出的体内监测

DOI:
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发表时间:
2013
期刊:
影响因子:
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通讯作者:
W. Nakamura
W. Nakamura
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作者:
W. Nakamura

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众所周知,视交叉上核(SCN)是行为的主要昼夜节律起搏器,反过来,运动节律也反映了SCN的功能。本文通过直接读出SCN和CLOCK突变小鼠的神经元活动作为有效的工具,报道了SCN和昼夜节律系统中运动活动之间的功能关联。进一步的行为分析揭示了昼夜节律振荡机制未知的可能性。
It is well established that the suprachiasmatic nucleus (SCN) is the master circadian pacemaker in behavior and vice versa locomotor activity rhythm reflect SCN function as well. In this paper, we reported functional correlations between the SCN and locomotor activity in circadian systems by using direct read out of neuronal activity in the SCN and Clock mutant mice as effective tools. Further behavioral analysis revealed a possibility of unknown circadian oscillatory mechanism.
DOI: 10.1126/science.8171325
发表时间: 1994-04-29
期刊: SCIENCE
影响因子: 56.9
作者:
VITATERNA, MH;KING, DP;TAKAHASHI, JS
通讯作者: TAKAHASHI, JS
DOI: 10.1126/science.288.5466.682
发表时间: 2000-04-28
期刊: SCIENCE
影响因子: 56.9
作者:
Yamazaki, S;Numano, R;Tei, H
通讯作者: Tei, H