Efficient mapping of Applied Biosystems SOLiD sequence data to a reference genome for functional genomic applications.
Efficient mapping of Applied Biosystems SOLiD sequence data to a reference genome for functional genomic applications.
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DOI:
10.1093/bioinformatics/btn512
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发表时间:
2008-12-01
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影响因子:
--
通讯作者:
Bergman NH
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文献类型:
--
作者:
Ondov BD;Varadarajan A;Passalacqua KD;Bergman NH
Summary: Here, we report the development of SOCS (short oligonucleotide color space), a program designed for efficient and flexible mapping of Applied Biosystems SOLiD sequence data onto a reference genome. SOCS performs its mapping within the context of ‘color space’, and it maximizes usable data by allowing a user-specified number of mismatches. Sequence census functions facilitate a variety of functional genomics applications, including transcriptome mapping and profiling, as well as ChIP-Seq. Availability: Executables, source code, and sample data are available at http://socs.biology.gatech.edu/ Contact: nickbergman@gatech.edu Supplementary information: Supplementary data are available at Bioinformatics Online.
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