Human Leukocyte Antigen-Disease Associations in Rheumatoid Arthritis.
Human Leukocyte Antigen-Disease Associations in Rheumatoid Arthritis.
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DOI：
10.1016/j.rdc.2017.04.003
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Holoshitz J
中科院分区：
文献类型：
--
作者：
van Drongelen V;Holoshitz J
The etiology and pathogenesis of rheumatoid arthritis (RA) are influenced by environmental and genetic risk factors. Shared epitope-coding HLA-DRB1 alleles increase RA risk and severity; however, the underlying mechanisms of action remain unclear. In contrast, several other DRB1 alleles protect against RA. Additionally, genome-wide association studies suggest that RA associates with other, HLA and non-HLA, genes but the relative contributions of such risk loci to RA are incompletely understood. Future research challenges include integrating the epidemiological and genomic data into validated arthritogenic pathways, and determining the mechanisms of interaction between RA risk genes and environmental influences.
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影响因子：
2.6
作者：
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通讯作者：
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影响因子：
4.9
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影响因子：
27.4
作者：
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DOI：
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1996-03-01
影响因子：
3.6
作者：
Gill, TJ
通讯作者：
Gill, TJ
DOI：
10.1196/annals.1423.009
发表时间：
2007-01-01
期刊：
AUTOIMMUNITY, PT B: NOVEL APPLICATIONS OF BASIC RESEARCH
影响因子：
--
作者：
Holoshitz, Joseph;Ling, Song
通讯作者：
Ling, Song