A prospective study of cerebral, frontal lobe, and temporal lobe volumes and neuropsychological performance in children with primary brain tumors treated with cranial radiation.
A prospective study of cerebral, frontal lobe, and temporal lobe volumes and neuropsychological performance in children with primary brain tumors treated with cranial radiation.
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DOI：
10.1002/cncr.30313
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发表时间：
2017-01-01
期刊：
影响因子：
6.2
通讯作者：
Terezakis, Stephanie
中科院分区：
文献类型：
--
作者：
Agbahiwe, Harold;Rashid, Arif;Horska, Alena;Mahone, E. Mark;Lin, Doris;McNutt, Todd;Cohen, Kenneth;Redmond, Kristin;Wharam, Moody, Jr.;Terezakis, Stephanie
关键词：
颅外放射（RT）是治疗小儿脑肿瘤的重要组成部分。然而，它可能会对发育中的大脑产生长期影响。这项前瞻性研究评估了颅RT对大脑、额叶和颞叶体积的影响及其与高级认知功能的相关性。对10例接受颅部RT治疗的原发性脑肿瘤儿童患者和14例年龄和性别匹配的健康儿童作为对照进行了评价。定量磁共振成像（MRI）和神经心理学（NP）评估（语言，记忆，听觉和视觉处理，和词汇）进行了基线和6个月，15个月，27个月后RT。年龄的影响，RT后的时间，和脑RT剂量对脑容量和NP性能进行了分析，使用线性混合效应（LME）模型分析。两组的脑容量均随年龄增长而显著增加（p=0.01）;这种体积增加在年幼儿童中更为明显。词汇表现与更大的脑容量（p=0.05）和更低的RT剂量（p=0.003）显著相关。RT剂量与脑体积之间无相关性。两组之间相应的神经心理学测试没有差异。这项前瞻性研究发现RT剂量，脑容量，并接受RT儿童的词汇发展率之间的显着关系。这项研究的结果提供了进一步的支持，旨在减少颅RT剂量在儿科人群的临床试验。
Cranial radiation (RT) is an important component in the treatment of pediatric brain tumors. However, it can result in long-term effects on the developing brain. This prospective study assessed the effects of cranial RT on cerebral, frontal lobe, and temporal lobe volumes and their correlation with higher cognitive functioning. Ten pediatric patients with primary brain tumors treated with cranial RT and 14 age- and sex-matched healthy children serving as controls were evaluated. Quantitative magnetic resonance imaging (MRIs) and neuropsychological (NP) assessments (language, memory, auditory and visual processing, and vocabulary) were performed at baseline and at 6, 15, and 27 months following RT. The effects of age, time since RT, and cerebral RT dose on brain volumes and NP performance were analyzed using linear mixed-effects (LME) models analyses. Cerebral volume increased significantly with age in both groups (p=0.01); this increase in volume was more pronounced in younger children. Vocabulary performance was found to be significantly associated with greater cerebral volume (p=0.05) and lower RT dose (p=0.003). No relationship was observed between RT dose and cerebral volume. There was no difference in the corresponding neuropsychological tests between the 2 groups. This prospective study found significant relationships among RT dose, cerebral volumes, and rate of vocabulary development among children receiving RT. The results of this study provide further support to clinical trials aimed at reducing cranial RT dose in the pediatric population.
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影响因子：
15.9
作者：
Reddick, WE;Glass, JO;Mulhern, RK
通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
Mulhern, RK
DOI：
10.1016/s0360-3016(99)00177-7
发表时间：
1999-08-01
影响因子：
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作者：
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通讯作者：
Kalifa, C