Circulating tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) in systemic sclerosis patients with elevated pulmonary arterial pressure.
Circulating tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) in systemic sclerosis patients with elevated pulmonary arterial pressure.
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DOI：
10.1155/2008/164134
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发表时间：
2008
影响因子：
4.6
通讯作者：
Petros SP
中科院分区：
文献类型：
--
作者：
Elias GJ;Ioannis M;Theodora P;Dimitrios PP;Despoina P;Kostantinos V;Charalampos K;Vassilios V;Petros SP
基质金属蛋白酶（MMPs）水平降低或其组织抑制剂（TIMPs）水平过高可能导致系统性硬化症（SSc）细胞外基质周转失调。在一项106例SSc患者的横断面研究中，我们测量了血清TIMP-4水平，TIMP-4优先表达于心血管结构，并与同时进行的肺动脉收缩压（PASP）、心肌性能和肺功能试验的超声心动图测量结果进行相关性研究。与对照组相比，SSc患者的TIMP-4水平显著升高，而MMP-9水平无显著升高。然而，在PASP测量值低于40 mmHg的患者亚组（n = 69）中，TIMP-4水平与对照组相当，无论是否存在弥漫性或有限的皮肤受累或肺纤维化。提示肺动脉高压的个体PASP测量值与TIMP-4血清水平升高相关（P = 0.03），与年龄、皮肤硬化程度或肺纤维化无关，提示TIMP-4激活在SSc中具有心肺血管特异性作用。
Decreased levels of matrix metalloproteinases (MMPs) or excess levels of their tissue inhibitors (TIMPs) may contribute to dysregulation of extracellular matrix turnover in systemic sclerosis (SSc). In a cross-sectional study of 106 SSc patients, we measured serum levels of TIMP-4 which is preferentially expressed in cardiovascular structures and searched for correlations with simultaneously performed echocardiography measurements of pulmonary artery systolic pressure (PASP), myocardial performance, and pulmonary function tests. TIMP-4, but not MMP-9, levels were significantly raised in patients with SSc than controls. However, in the subgroup of patients with PASP measurements lower to 40 mmHg (n = 69), TIMP-4 levels were comparable to controls irrespective of the presence of diffuse or limited skin involvement, or lung fibrosis. Individual PASP measurements suggestive of pulmonary hypertension were associated with increased TIMP-4 serum levels (P = .03), independently of age, extent of skin sclerosis, or lung fibrosis, suggesting a cardiopulmonary vasculature-specific role of TIMP-4 activation in SSc.
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影响因子：
4.7
作者：
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通讯作者：
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DOI：
10.1111/j.1365-2362.2006.01686.x
发表时间：
2006-09-01
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DOI：
10.1016/s0735-1097(02)02059-4
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2002-09-04
影响因子：
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影响因子：
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