Maternally derived anti-helminth antibodies predict offspring survival in a wild mammal.
Maternally derived anti-helminth antibodies predict offspring survival in a wild mammal.
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母体来源的抗蠕虫抗体可以预测野生哺乳动物后代的存活率。
DOI：
10.1098/rspb.2020.1931
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发表时间：
2020-11-25
期刊：
影响因子：
--
通讯作者：
Nussey DH
中科院分区：
文献类型：
--
作者：
Sparks AM;Hayward AD;Watt K;Pilkington JG;Pemberton JM;Johnston SE;McNeilly TN;Nussey DH
抗体从母亲转移到后代为人类、家畜和实验动物的早期生命提供了防止后代感染的重要保护。然而，很少有研究测试母源抗体转移变异对野生后代健康的影响。此外，将抗体的免疫保护作用与其与母亲提供的营养资源的关联分开是很困难的。在这里，我们测量了 25 年来新生（小于 10 天）野生索伊羊的血浆总抗体和寄生虫特异性抗体水平，以量化母体抗体转移的变化并测试其与后代存活的关系。母体抗体转移是通过母亲年龄和之前的抗体反应来预测的，并且在不同年份的母亲中是一致的。新生儿总 IgG 抗体水平与早期生长呈正相关，表明它们反映了营养转移。新生儿寄生虫特异性 IgG 水平可正向预测第一年存活率，与羔羊体重、总 IgG 水平和随后的羔羊寄生虫特异性抗体水平无关。这种关系部分是通过与寄生虫负担的间接负相关来调节的。我们发现，母体抗体转移的女性变异可能对后代生长、寄生虫负担和野外适应性产生长期影响，并且可能影响自然发生的宿主-寄生虫动态。
The transfer of antibodies from mother to offspring provides crucial protection against infection to offspring during early life in humans and domestic and laboratory animals. However, few studies have tested the consequences of variation in maternal antibody transfer for offspring fitness in the wild. Further, separating the immunoprotective effects of antibodies from their association with nutritional resources provided by mothers is difficult. Here, we measured plasma levels of total and parasite-specific antibodies in neonatal (less than 10 days old) wild Soay sheep over 25 years to quantify variation in maternal antibody transfer and test its association with offspring survival. Maternal antibody transfer was predicted by maternal age and previous antibody responses, and was consistent within mothers across years. Neonatal total IgG antibody levels were positively related to early growth, suggesting they reflected nutritional transfer. Neonatal parasite-specific IgG levels positively predicted first-year survival, independent of lamb weight, total IgG levels and subsequent lamb parasite-specific antibody levels. This relationship was partly mediated via an indirect negative association with parasite burden. We show that among-female variation in maternal antibody transfer can have long-term effects on offspring growth, parasite burden and fitness in the wild, and is likely to impact naturally occurring host–parasite dynamics.
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影响因子：
3.9
作者：
Hayward AD;Moorad J;Regan CE;Berenos C;Pilkington JG;Pemberton JM;Nussey DH
通讯作者：
Nussey DH
影响因子：
2
作者：
Gelman, Andrew
通讯作者：
Gelman, Andrew
影响因子：
3.1
作者：
Blackwell, NM;Else, KJ
通讯作者：
Else, KJ
影响因子：
56.9
作者：
Coulson, T;Catchpole, EA;Grenfell, BT
通讯作者：
Grenfell, BT
影响因子：
2.8
作者：
Grindstaff, Jennifer L.
通讯作者：
Grindstaff, Jennifer L.