The STING pathway and regulation of innate immune signaling in response to DNA pathogens.
The STING pathway and regulation of innate immune signaling in response to DNA pathogens.
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DOI：
10.1007/s00018-010-0605-2
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发表时间：
2011-04
影响因子：
8
通讯作者：
Barber, Glen N.
中科院分区：
文献类型：
--
作者：
Ishikawa, Hiroki;Barber, Glen N.
先天免疫系统已经进化出多种感知机制来检测和对抗微生物的入侵。这些途径包括toll样受体（TLR）、细胞质、核苷酸结合寡聚化结构域（NOD）样受体和rig - i样解旋酶（RLH）途径。然而，细胞如何检测病原体相关DNA以触发宿主防御，包括干扰素的产生，仍有待完全澄清。了解这些过程可能对我们如何理解和治疗各种微生物相关疾病（包括病毒相关癌症以及自身免疫性疾病）具有深远的意义。最近，一种被称为STING（干扰素基因刺激因子）的内质网相关分子被分离出来，并被证明对响应细胞质DNA调节IFN的产生至关重要。在这里，我们回顾了与外源DNA检测有关的最新发现，包括STING和炎性体途径的重要性以及先天信号传导过程的触发。
The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, nucleotide binding oligomerization domain (NOD)-like receptor and RIG-I-like helicase (RLH) pathways. However, how the cell detects pathogen-associated DNA to trigger host defense, including the production of interferon, remains to be fully clarified. Understanding these processes could have profound implications into how we understand and treat a variety of microbial-related disease, including viral-associated cancers, as well as autoimmune disorders. Recently, an endoplasmic reticulum-associated molecule referred to as STING (for stimulator of interferon genes) was isolated and shown to be critical for regulating the production of IFN in response to cytoplasmic DNA. Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes.
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