Insights into intercellular receptor-ligand binding kinetics in cell communication.
Insights into intercellular receptor-ligand binding kinetics in cell communication.
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DOI：
10.3389/fbioe.2022.953353
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发表时间：
2022
影响因子：
5.7
通讯作者：
Li, Long
中科院分区：
文献类型：
--
作者：
An, Chenyi;Wang, Xiaohuan;Song, Fan;Hu, Jinglei;Li, Long
关键词：
细胞间通讯对于细胞感知、响应和适应环境线索和刺激至关重要。细胞间通讯过程涉及多个长度尺度，由膜锚定受体和配体的特异性结合介导。深入了解二维受体-配体结合动力学对于理解许多生理和病理过程以及刺激药物设计和发现的新策略具有重要意义。为此，人们通过实验、理论分析和数值模拟等手段对细胞间受体-配体结合动力学的控制机制进行了深入的研究。已经确定的是，受体-配体相互作用发生的细胞微环境起着至关重要的作用。本文从蛋白质-膜相互作用、生物力学和生物电微环境三个方面综述了生物电调控的实验观察、机制及其生物医学意义和应用。同时，我们介绍了建模方法以及为处理不同尺度问题而开发的实验技术。我们还概述了未来的发展方向，以推进该领域，并强调，建立系统的理解，这些调控因素的耦合作用，可以大大有助于药物开发。
Cell-cell communication is crucial for cells to sense, respond and adapt to environmental cues and stimuli. The intercellular communication process, which involves multiple length scales, is mediated by the specific binding of membrane-anchored receptors and ligands. Gaining insight into two-dimensional receptor-ligand binding kinetics is of great significance for understanding numerous physiological and pathological processes, and stimulating new strategies in drug design and discovery. To this end, extensive studies have been performed to illuminate the underlying mechanisms that control intercellular receptor-ligand binding kinetics via experiment, theoretical analysis and numerical simulation. It has been well established that the cellular microenvironment where the receptor-ligand interaction occurs plays a vital role. In this review, we focus on the advances regarding the regulatory effects of three factors including 1) protein-membrane interaction, 2) biomechanical force, and 3) bioelectric microenvironment to summarize the relevant experimental observations, underlying mechanisms, as well as their biomedical significances and applications. Meanwhile, we introduce modeling methods together with experiment technologies developed for dealing with issues at different scales. We also outline future directions to advance the field and highlight that building up systematic understandings for the coupling effects of these regulatory factors can greatly help pharmaceutical development.
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影响因子：
5.7
作者：
Cho HY;Choi JH;Kim KJ;Shin M;Choi JW
通讯作者：
Choi JW
DOI：
10.13865/j.cnki.cjbmb.2017.10.01
发表时间：
2017-10-01
期刊：
Zhongguo Shengwu Huaxue yu Fenzi Shengwu Xuebao
影响因子：
--
作者：
An Chen-Yi;Fei Pan-Yu;Chen Wei
通讯作者：
Chen Wei
影响因子：
56.9
作者：
BELL, GI
通讯作者：
BELL, GI
影响因子：
17.1
作者：
Choe JH;Watchmaker PB;Simic MS;Gilbert RD;Li AW;Krasnow NA;Downey KM;Yu W;Carrera DA;Celli A;Cho J;Briones JD;Duecker JM;Goretsky YE;Dannenfelser R;Cardarelli L;Troyanskaya O;Sidhu SS;Roybal KT;Okada H;Lim WA
通讯作者：
Lim WA
影响因子：
64.8
作者：
Ben-Chaim, Yair;Chanda, Baron;Parnas, Hanna
通讯作者：
Parnas, Hanna