Emerging SARS-CoV-2 Variants: Genetic Variability and Clinical Implications.
Emerging SARS-CoV-2 Variants: Genetic Variability and Clinical Implications.
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DOI：
10.1007/s00284-021-02724-1
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发表时间：
2021-12-14
影响因子：
2.6
通讯作者：
Tomar S
中科院分区：
文献类型：
--
作者：
Dubey A;Choudhary S;Kumar P;Tomar S
2020年COVID-19病例的突然增加以及快速传播的变种不断出现，在全球范围内造成了令人担忧的局面。除了在设计和开发疫苗以对抗这种致命的大流行病方面不断取得进展外，还经常报告新的变异，这些变异具有迅速超过现有流行变异群体的突变。随着人们越来越担心突变对疫苗效力的影响，传染性增加、免疫逃逸和诊断失败是导致更多致命COVID-19浪潮的其他担忧。尽管SARS-CoV-2新变体中的抗原漂移现象仍未得到验证，但可以设想，病毒正在获得新的突变，作为快速传播或克服宿主细胞免疫抗性的适应性优势。自2019年首次出现以来，已经观察到SARS-CoV-2的相当大的进化，尽管在表征突变的测序工作方面取得了进展，但尚未分析它们在许多变体中的影响。本文提供了大量的文献综述，解释了全球传播的SARS-CoV-2的新变种，病毒基因组中的关键突变，以及这些新突变对目前用于对抗这种流行病的预防和治疗策略的可能影响。感染率、死亡率和住院率的上升可以通过大规模疫苗接种、社交距离、更好地管理现有的医疗基础设施以及优先考虑基因组测序以更好地进行血清监测研究和社区跟踪来解决。
The sudden rise in COVID-19 cases in 2020 and the incessant emergence of fast-spreading variants have created an alarming situation worldwide. Besides the continuous advancements in the design and development of vaccines to combat this deadly pandemic, new variants are frequently reported, possessing mutations that rapidly outcompeted an existing population of circulating variants. As concerns grow about the effects of mutations on the efficacy of vaccines, increased transmissibility, immune escape, and diagnostic failures are few other apprehensions liable for more deadly waves of COVID-19. Although the phenomenon of antigenic drift in new variants of SARS-CoV-2 is still not validated, it is conceived that the virus is acquiring new mutations as a fitness advantage for rapid transmission or to overcome immunological resistance of the host cell. Considerable evolution of SARS-CoV-2 has been observed since its first appearance in 2019, and despite the progress in sequencing efforts to characterize the mutations, their impacts in many variants have not been analyzed. The present article provides a substantial review of literature explaining the emerging variants of SARS-CoV-2 circulating globally, key mutations in viral genome, and the possible impacts of these new mutations on prevention and therapeutic strategies currently administered to combat this pandemic. Rising infections, mortalities, and hospitalizations can possibly be tackled through mass vaccination, social distancing, better management of available healthcare infrastructure, and by prioritizing genome sequencing for better serosurveillance studies and community tracking.
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DOI：
10.1016/j.meegid.2021.104869
发表时间：
2021-08
期刊：
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子：
--
作者：
González-Candelas F;Shaw MA;Phan T;Kulkarni-Kale U;Paraskevis D;Luciani F;Kimura H;Sironi M
通讯作者：
Sironi M
SARS-COV-2血统的估计可传播和影响B.1.1.7在英国。
DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
DOI：
10.1084/jem.20210198
发表时间：
2021-05-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Baum A;Kyratsous CA
通讯作者：
Kyratsous CA
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Gordon, David E.;Jang, Gwendolyn M.;Krogan, Nevan J.
通讯作者：
Krogan, Nevan J.