Analysis of genetic interaction networks shows that alternatively spliced genes are highly versatile.
Analysis of genetic interaction networks shows that alternatively spliced genes are highly versatile.
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DOI：
10.1371/journal.pone.0055671
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lovell SC
中科院分区：
文献类型：
--
作者：
Talavera D;Sheoran R;Lovell SC
选择性剪接有可能增加转录组和蛋白质组的多样性。当一个基因产生一个以上的转录本时，它们通常是如此不同，以至于它们不太可能具有相同的功能。然而，目前尚不清楚选择性剪接是否通常导致基因参与多个生物过程，或者它是否改变了单个过程中的功能。我们知道，遗传相互作用发生在功能相关的基因之间，我们用它们作为功能多样性的代理，并分析了两个特征良好的模式生物的基因集：秀丽隐杆线虫和果蝇。使用网络分析，我们发现很少有基因是功能同质的（只参与一些功能相关的生物过程）。此外，选择性剪接基因和具有单一转录物的基因之间存在差异;具体而言，具有选择性剪接的基因平均参与更多的生物过程。最后，我们认为，特定功能类以外的因素决定了基因是否是选择性剪接。
Alternative splicing has the potential to increase the diversity of the transcriptome and proteome. Where more than one transcript arises from a gene they are often so different that they are quite unlikely to have the same function. However, it remains unclear if alternative splicing generally leads to a gene being involved in multiple biological processes or whether it alters the function within a single process. Knowing that genetic interactions occur between functionally related genes, we have used them as a proxy for functional versatility, and have analysed the sets of genes of two well-characterised model organisms: Caenorhabditis elegans and Drosophila melanogaster. Using network analyses we find that few genes are functionally homogenous (only involved in a few functionally-related biological processes). Moreover, there are differences between alternatively spliced genes and genes with a single transcript; specifically, genes with alternatively splicing are, on average, involved in more biological processes. Finally, we suggest that factors other than specific functional classes determine whether a gene is alternatively spliced.
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