Therapeutic Potential of a Scorpion Venom-Derived Antimicrobial Peptide and Its Homologs Against Antibiotic-Resistant Gram-Positive Bacteria.
Therapeutic Potential of a Scorpion Venom-Derived Antimicrobial Peptide and Its Homologs Against Antibiotic-Resistant Gram-Positive Bacteria.
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DOI：
10.3389/fmicb.2018.01159
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发表时间：
2018
影响因子：
5.2
通讯作者：
Cao Z
中科院分区：
文献类型：
--
作者：
Liu G;Yang F;Li F;Li Z;Lang Y;Shen B;Wu Y;Li W;Harrison PL;Strong PN;Xie Y;Miller K;Cao Z
The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for the development of effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted a great deal of attention as a possible solution to the increasing problem of antibiotic-resistant bacteria. Marcin-18 was identified from the scorpion Mesobuthus martensii at both DNA and protein levels. The genomic sequence revealed that the marcin-18 coding gene contains a phase-I intron with a GT-AG splice junction located in the DNA region encoding the N-terminal part of signal peptide. The peptide marcin-18 was also isolated from scorpion venom. A protein sequence homology search revealed that marcin-18 shares extremely high sequence identity to the AMPs meucin-18 and megicin-18. In vitro, chemically synthetic marcin-18 and its homologs (meucin-18 and megicin-18) showed highly potent inhibitory activity against Gram-positive bacteria, including some clinical antibiotic-resistant strains. Importantly, in a mouse acute peritonitis model, these peptides significantly decreased the bacterial load in ascites and rescued nearly all mice heavily infected with clinical methicillin-resistant Staphylococcus aureus from lethal bacteremia. Peptides exerted antimicrobial activity via a bactericidal mechanism and killed bacteria through membrane disruption. Taken together, marcin-18 and its homologs have potential for development as therapeutic agents for treating antibiotic-resistant, Gram-positive bacterial infections.
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影响因子：
3.7
作者：
Cao L;Dai C;Li Z;Fan Z;Song Y;Wu Y;Cao Z;Li W
通讯作者：
Li W
DOI：
10.1016/j.toxicon.2014.06.006
发表时间：
2014-09
期刊：
Toxicon : official journal of the International Society on Toxinology
影响因子：
--
作者：
Harrison PL;Abdel-Rahman MA;Miller K;Strong PN
通讯作者：
Strong PN
蝎子 Mesobuthus eupeus 中两种线性阳离子抗疟肽的表征
影响因子：
3.9
作者：
Gao, Bin;Xu, Jia;Zhu, Shunyi
通讯作者：
Zhu, Shunyi
影响因子：
6.4
作者：
Hou, Zheng;Lu, Jun;Luo, Xiaoxing
通讯作者：
Luo, Xiaoxing
影响因子：
5.8
作者：
Gautier, Romain;Douguet, Dominique;Drin, Guillaume
通讯作者：
Drin, Guillaume