Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts.
Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts.
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DOI：
10.1038/s41467-023-37193-6
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发表时间：
2023-03-17
影响因子：
16.6
通讯作者：
Noth, Imre
中科院分区：
文献类型：
--
作者：
Adegunsoye, Ayodeji;Newton, Chad A.;Oldham, Justin M.;Ley, Brett;Lee, Cathryn T.;Linderholm, Angela L.;Chung, Jonathan H.;Garcia, Nicole;Zhang, Da;Vij, Rekha;Guzy, Robert;Jablonski, Renea;Bag, Remzi;Voogt, Rebecca S.;Ma, Shwu-Fan;Sperling, Anne I.;Raghu, Ganesh;Martinez, Fernando J.;Strek, Mary E.;Wolters, Paul J.;Garcia, Christine Kim;Pierce, Brandon L.;Noth, Imre
肺纤维化(PF)的特点是严重的瘢痕形成和低存活率。我们在不同种族的PF队列中调查了白细胞端粒长度(LTL)与年龄和死亡率的关系。对按种族/民族分层的PF参与者的LTL测量与年龄和全因死亡率进行了评估，并与对照组进行了比较。用广义线性模型评估年龄-LTL关系，用Cox比例风险模型估计危险比，用Cochran-Armitage检验评估LTL的四分位数。标准化LTL随着年龄的增长而缩短；在对照组中，这种关联在PF中得到加强(R = −0.28；P <； 0.0001)。在PF中，年龄和性别调整后的LTL低于中位数，在所有种族中一致预测更糟糕的死亡率(白人，HR = 2.21，95%CI = 1.79-2.72；黑人，HR = 2.22，95%CI = 1.05-4.66；西班牙裔，HR = 3.40，95%CI = 1.88-6.14；亚裔，HR = 2.11，95%CI = 0.55-8.23)。LTL与实际年龄一致相关，是跨种族群体预测PF死亡率的生物标志物。在不同种族的肺纤维化人群中，端粒长度与年龄和死亡率的相关性尚不清楚。在这里，作者表明，白细胞端粒长度与年龄相关，并可预测不同种族组肺纤维化的死亡率。
Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated the association of leukocyte telomere length (LTL) with chronological age and mortality across racially diverse PF cohorts. LTL measurements among participants with PF stratified by race/ethnicity were assessed in relation to age and all-cause mortality, and compared to controls. Generalized linear models were used to evaluate the age-LTL relationship, Cox proportional hazards models were used for hazard ratio estimation, and the Cochran–Armitage test was used to assess quartiles of LTL. Standardized LTL shortened with increasing chronological age; this association in controls was strengthened in PF (R = −0.28; P < 0.0001). In PF, age- and sex-adjusted LTL below the median consistently predicted worse mortality across all racial groups (White, HR = 2.21, 95% CI = 1.79–2.72; Black, HR = 2.22, 95% CI = 1.05–4.66; Hispanic, HR = 3.40, 95% CI = 1.88–6.14; and Asian, HR = 2.11, 95% CI = 0.55–8.23). LTL associates uniformly with chronological age and is a biomarker predictive of mortality in PF across racial groups. The association of telomere length with age and mortality across racially diverse pulmonary fibrosis populations is unknown. Here, the authors show that leukocyte telomere length associates with chronologic age and is predictive of mortality in pulmonary fibrosis across racial groups.
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影响因子：
120.7
作者：
Dwyer-Lindgren, Laura;Bertozzi-Villa, Amelia;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
5
作者：
通讯作者：
--
DOI：
10.1126/science.aaz6876
发表时间：
2020-09-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Demanelis K;Jasmine F;Chen LS;Chernoff M;Tong L;Delgado D;Zhang C;Shinkle J;Sabarinathan M;Lin H;Ramirez E;Oliva M;Kim-Hellmuth S;Stranger BE;Lai TP;Aviv A;Ardlie KG;Aguet F;Ahsan H;GTEx Consortium;Doherty JA;Kibriya MG;Pierce BL
通讯作者：
Pierce BL
DOI：
10.1002/art.22532
发表时间：
2007-03-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
McNearney, Terry A.;Reveille, John D.;Mayes, Maureen D.
通讯作者：
Mayes, Maureen D.
DOI：
10.1164/rccm.200804-550oc
发表时间：
2008-10-01
影响因子：
24.7
作者：
Cronkhite, Jennifer T.;Xing, Chao;Garcia, Christine Kim
通讯作者：
Garcia, Christine Kim