IgA modulates respiratory dysfunction as a sequela to pulmonary chlamydial infection as neonates.
IgA modulates respiratory dysfunction as a sequela to pulmonary chlamydial infection as neonates.
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IgA 调节呼吸功能障碍，这是新生儿肺部衣原体感染的后遗症。
DOI：
10.1093/femspd/ftv121
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发表时间：
2016
影响因子：
3.3
通讯作者：
Arulanandam,BernardP
中科院分区：
文献类型：
--
作者：
Lanka,GopalaKrishnaKoundinya;Yu,Jieh-Juen;Gong,Siqi;Gupta,Rishein;Mustafa,ShamimunisaB;Murthy,AshleshK;Zhong,Guangming;Chambers,JamesP;Guentzel,MNeal;Arulanandam,BernardP
新生儿衣原体感染与儿童和成人哮喘和气道高反应性等严重后遗症有关。我们之前的研究表明Th-1型细胞因子、IL-12和IFN-γ在新生儿肺衣原体攻击保护中的重要性；然而，体液防御臂的作用尚未得到阐明。我们假设b细胞和IgA（主要的粘膜抗体）在新生儿预防衣原体感染的呼吸道后遗症中起保护作用。我们对新生小鼠的研究显示，所有WT和IgA缺陷（IgA−/−）小鼠在出生后一天存活于亚致命性肺衣原体muridarum挑战中，随着时间的推移，细菌负荷也有类似的减少。相反，所有b细胞缺陷（μMT）小鼠在相同的攻击剂量下死于感染，这与未能控制肺部细菌负荷有关。尽管IgA对细菌清除可能并不重要，但我们观察到IgA - / -小鼠在攻击后5周表现出更大的呼吸功能障碍。具体而言，比较呼吸功能分析显示，在IgA−/−动物中，P-V回路明显向上移动，并且具有更高的动态抗性。这项研究为IgA在新生儿中对肺衣原体感染引起的呼吸道病理后遗症的保护作用提供了见解。
NeonatalChlamydialung infections are associated with serious sequelae such as asthma and airway hyper-reactivity in children and adults. Our previous studies demonstrated the importance of Th-1 type cytokines, IL-12 and IFN-γ in protection against neonatal pulmonary chlamydial challenge; however, the role of the humoral arm of defense has not been elucidated. We hypothesized that B-cells and IgA, the major mucosal antibody, play a protective role in newborns against development of later life respiratory sequelae toChlamydiainfection. Our studies using neonatal mice revealed that all WT and IgA-deficient (IgA−/−) animals survived a sublethal pulmonaryChlamydia muridarumchallenge at one day after birth with similar reduction in bacterial burdens over time. In contrast, all B-cell-deficient (μMT) mice succumbed to infection at the same challenge dose correlating to failure to control bacterial burdens in the lungs. Although IgA may not be important for bacterial clearance, we observed IgA−/−mice displayed greater respiratory dysfunction 5 weeks post challenge. Specifically, comparative respiratory functional analyses revealed a significant shift upward in P–V loops, and higher dynamic resistance in IgA−/−animals. This study provides insight(s) into the protective role of IgA in neonates against pulmonary chlamydial infection induced respiratory pathological sequelae observed later in life.
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肿瘤中的克隆相互作用
影响因子：
64.8
作者：
Michael Woodruff;J. Ansell;G. Forbes;J. Gordon;D. Burton;H. Micklem
通讯作者：
H. Micklem
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影响因子：
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作者：
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DOI：
10.1016/0025-5564(80)90093-0
发表时间：
1980
期刊：
Bellman Prize in Mathematical Biosciences
影响因子：
--
作者：
P. Iannaccone
通讯作者：
P. Iannaccone
DOI：
10.1084/jem.150.4.878
发表时间：
1979-10-01
期刊：
The Journal of experimental medicine
影响因子：
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作者：
Reddy AL;Fialkow PJ
通讯作者：
Fialkow PJ
影响因子：
64.8
作者：
HENNINGS, H;SHORES, R;YUSPA, SH
通讯作者：
YUSPA, SH