Induction chemotherapy in advanced head and neck cancer. A Radiation Therapy Oncology Group Study.
Induction chemotherapy in advanced head and neck cancer. A Radiation Therapy Oncology Group Study.
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晚期头颈癌的诱导化疗。
DOI：
10.1001/archotol.1987.01860020085018
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
S. Leibel
中科院分区：
文献类型：
--
作者：
J. Jacobs;T. Pajak;J. Kinzie;M. al;L. Davis;G. Hanks;I. Weigensberg;S. Leibel
顺铂（cis-platinum，100 mg/m2）和氟尿嘧啶（fluorouracil，1000 mg/m2/d），每3周1次，每次120小时，共3个疗程，单中心水平的总有效率为93%，完全临床反应为54%。在放射治疗肿瘤学小组中测试了相同的组合，以评价该组合的有效性和可行性。总体缓解率为86%，完全临床缓解率为38%。42例患者中只有27例完成了计划的手术。化疗和放疗的依从性明显更好。手术切除或术后放射治疗后没有额外的发病率被确定为继发于诱导化疗。我们的结论是，顺铂和氟尿嘧啶联合输注是有效的，在晚期，以前未经治疗的头颈部癌患者的完全临床反应率高。
Cisplatin (cis-platinum, 100 mg/m2) and fluorouracil (1000 mg/m2/d), for 120 hours' infusion every three weeks for three courses, produced a 93% overall response rate and a 54% complete clinical response at the single-institution level. The same combination was tested in the Radiation Therapy Oncology Group to evaluate the effectiveness and feasibility of this combination. An overall response rate of 86% was obtained, with a 38% complete clinical response. Only 27 of 42 patients completed planned surgery. Compliance with chemotherapy and radiation therapy was substantially better. No additional morbidity after surgical resection or postoperative radiation therapy was identified as secondary to the induction chemotherapy. We conclude that the combination of cisplatin and fluorouracil infusion is effective, with high complete clinical response rate in patients with advanced, previously untreated head and neck carcinoma.
头颈鳞癌术前顺铂和博莱霉素治疗。
DOI：
10.1001/archotol.1981.00790470031008
发表时间：
1981
期刊：
Archives of otolaryngology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Baker,SR;Makuch,RW;Wolf,GT
通讯作者：
Wolf,GT
影响因子：
45.3
作者：
ANDERSON, JR;CAIN, KC;GELBER, RD
通讯作者：
GELBER, RD