Microfluidic proportional flow controller.

Microfluidic proportional flow controller.
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DOI:
10.1088/0960-1317/20/11/115020
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发表时间:
2010-10-15
期刊:
Journal of micromechanics and microengineering : structures, devices, and systems
影响因子:
--
通讯作者:
Irimia D
Irimia D
中科院分区:
其他
文献类型:
--
作者:
Prentice-Mott H;Toner M;Irimia D

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在微流控芯片中,精确的流量控制对于许多微尺度的生化分析和实验是非常重要的。虽然已经实现了几种控制流体流动的技术,无论是在芯片上还是在芯片外,这些技术都可以提供高速或高精度控制,但很少能同时实现这两种控制。在这里,我们描述了一种新的芯片上,气动激活的流量控制器,允许快速和精确地控制通过微流体通道的流量。实验结果表明,新的比例流量控制器具有大约250ms的响应时间,而我们的数值模拟表明,使用不同的执行方案可以实现更快的执行速度,低至大约50ms。
Precise flow control in microfluidic chips is important for many biochemical assays and experiments at microscale. While several technologies for controlling fluid flow have been implemented either on- or off-chip, these can provide either high-speed or high-precision control, but seldom could accomplish both at the same time. Here we describe a new on-chip, pneumatically activated flow controller that allows for fast and precise control of the flow rate through a microfluidic channel. Experimental results show that the new proportional flow controllers exhibited a response time of approximately 250 ms, while our numerical simulations suggest that faster actuation down to approximately 50 ms could be achieved with alternative actuation schemes.
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