Lipid-Based Nutrient Supplementation Increases High-Density Lipoprotein (HDL) Cholesterol Efflux Capacity and Is Associated with Changes in the HDL Glycoproteome in Children.
Lipid-Based Nutrient Supplementation Increases High-Density Lipoprotein (HDL) Cholesterol Efflux Capacity and Is Associated with Changes in the HDL Glycoproteome in Children.
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DOI：
10.1021/acsomega.1c04811
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发表时间：
2021-11-30
期刊：
影响因子：
4.1
通讯作者：
Zivkovic AM
中科院分区：
文献类型：
--
作者：
Hong BV;Zhu C;Wong M;Sacchi R;Rhodes CH;Kang JW;Arnold CD;Adu-Afarwuah S;Lartey A;Oaks BM;Lebrilla CB;Dewey KG;Zivkovic AM
在加纳进行的国际基于脂质的营养补充剂双生子试验中，产前加产后小剂量基于脂质的营养补充剂（SQ - LNS）改善了儿童18个月时的生长情况。在这项次要结局分析中，我们确定了与产前铁和叶酸（IFA）补充剂相比，SQ - LNS是否能提高80名18个月大儿童的高密度脂蛋白（HDL）颗粒的胆固醇流出能力（CEC），并改变其脂质组学、蛋白质组学或糖蛋白质组学组成。与IFA组相比，SQ - LNS组儿童的HDL CEC更高（20.9 ± 4.1%对19.4 ± 3.3%；单侧p = 0.038）。两组之间HDL的脂质组学或蛋白质组学组成没有差异。在分析的163种糖肽中，有12种被SQ - LNS显著改变，但在进行多重检验校正后，组间差异均无统计学意义。探索性分析显示，在监测的33种与HDL相关的蛋白质中，有6种在干预组之间糖肽富集程度不同，163种糖肽中有6种与CEC相关。我们得出结论，产前加产后的SQ - LNS可能会改变儿童HDL蛋白质糖谱并提高HDL颗粒的CEC，这可能对后续儿童健康结局产生影响。该试验在 注册为NCT00970866。（原文中注册网址缺失）
Prenatal plus postnatal small-quantity lipid-based nutrient supplements (SQ-LNS) improved child growth at 18 months in the International Lipid-Based Nutrient Supplements DYAD trial in Ghana. In this secondary outcome analysis, we determined whether SQ-LNS versus prenatal iron and folic acid (IFA) supplementation improves the cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) particles and alters their lipidomic, proteomic, or glycoproteomic composition in a subset of 80 children at 18 months of age. HDL CEC was higher among children in the SQ-LNS versus IFA group (20.9 ± 4.1 vs 19.4 ± 3.3%; one-tailed p = 0.038). There were no differences in HDL lipidomic or proteomic composition between groups. Twelve glycopeptides out of the 163 analyzed were significantly altered by SQ-LNS, but none of the group differences remained significant after correction for multiple testing. Exploratory analysis showed that 6 out of the 33 HDL-associated proteins monitored differed in glycopeptide enrichment between intervention groups, and 6 out of the 163 glycopeptides were correlated with CEC. We conclude that prenatal plus postnatal SQ-LNS may modify HDL protein glycoprofiles and improve the CEC of HDL particles in children, which may have implications for subsequent child health outcomes. This trial was registered at as NCT00970866.
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影响因子：
168.9
作者：
Adair, Linda S.;Fall, Caroline H. D.;Osmond, Clive;Stein, Aryeh D.;Martorell, Reynaldo;Ramirez-Zea, Manuel;Sachdev, Harshpal Singh;Dahly, Darren L.;Bas, Isabelita;Norris, Shane A.;Micklesfield, Lisa;Hallal, Pedro;Victora, Cesar G.
通讯作者：
Victora, Cesar G.
影响因子：
3.4
作者：
Arimond, Mary;Zeilani, Mamane;Dewey, Kathryn G.
通讯作者：
Dewey, Kathryn G.
影响因子：
4.2
作者：
Adu-Afarwuah, Seth;Young, Rebecca T.;Dewey, Kathryn G.
通讯作者：
Dewey, Kathryn G.
影响因子：
158.5
作者：
Barter, Philip;Gotto, Antonio M.;Fruchart, Jean-Charles
通讯作者：
Fruchart, Jean-Charles
影响因子：
7.1
作者：
Adu-Afarwuah, Seth;Lartey, Anna;Dewey, Kathryn G.
通讯作者：
Dewey, Kathryn G.