Strain difference of the mouse in manifestation of hydrocephalus following prenatal methylmercury exposure.
Strain difference of the mouse in manifestation of hydrocephalus following prenatal methylmercury exposure.
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产前甲基汞暴露后小鼠脑积水表现的应变差异。
DOI：
10.1002/tera.1420410212
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Y. Kajiwara
中科院分区：
文献类型：
--
作者：
M. Inouye;Y. Kajiwara
遗传背景可能影响脑积水的易感性。在本实验中，我们比较的表现，脑积水以下产前甲基汞暴露的菌株之间的小鼠偶发性发展或从来没有发展自发性脑积水。在妊娠第14天至第17天的其中一天，对B10.D2同类品系的妊娠小鼠单次口服剂量为10 mg/kg氯化甲基汞，并允许分娩和饲养其幼崽。在妊娠第14、15、16或17天给药后30日龄的后代中，明显脑积水的发生率分别为67、88、75和48%;假给药和未给药后代的发生率分别为5和4%。此外，有些大脑显示侧脑室轻微扩张。C57 BL/10（B10）或DBA/2（D2）品系的妊娠雌性在妊娠第15天也用10 mg/kg甲基汞处理。未给药和给药B10小鼠30日龄时脑积水的发生率分别为0.8%和54%。D2小鼠未发生脑积水。脑积水是一种交通型。大脑导水管闭塞伴胶质反应和小脑尾侧移位被认为是继发性变化。结果表明，小鼠对甲基汞诱导的脑积水的易感性受遗传控制。
Genetic background may influence susceptibility to hydrocephalus. In the present experiment we compared the manifestation of hydrocephalus following prenatal methylmercury exposure among strains of mice which sporadically develop or never develop spontaneous hydrocephalus. Pregnant mice of the B10.D2 congenic strain were given a single oral dose of 10 mg/kg methylmercuric chloride on one of days 14 through 17 of pregnancy and allowed to give birth and rear their litters. The incidence of grossly apparent hydrocephalus in the offspring at 30 days of age following treatment on day 14, 15, 16, or 17 of pregnancy was 67, 88, 75, and 48%, respectively; that of sham-treated and untreated offspring was 5 and 4%, respectively. In addition, there were some brains showing slight dilatation of the lateral ventricles. Pregnant females of C57BL/10 (B10) or DBA/2 (D2) strain were also treated with 10 mg/kg methylmercury on day 15 of pregnancy. The incidence of hydrocephalus at 30 days of age in untreated and dosed B10 mice was 0.8 and 54%, respectively. Hydrocephalus failed to develop in D2 mice. The hydrocephalus is a communicating type. Occlusion of the cerebral aqueduct with glial reaction and caudal displacement of the cerebellum are considered to be secondary changes. The results indicate that the susceptibility to methylmercury-induced hydrocephalus is under genetic control in mice.
DOI：
10.1002/tera.1420180216
发表时间：
1978-01-01
期刊：
TERATOLOGY
影响因子：
--
作者：
HARADA, M
通讯作者：
HARADA, M