Meglumine antimoniate is more effective than sodium stibogluconate in the treatment of cutaneous leishmaniasis.
Meglumine antimoniate is more effective than sodium stibogluconate in the treatment of cutaneous leishmaniasis.
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DOI：
10.3109/09546634.2015.1054778
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Satoskar AR
中科院分区：
文献类型：
--
作者：
Yesilova Y;Surucu HA;Ardic N;Aksoy M;Yesilova A;Oghumu S;Satoskar AR
葡萄糖酸锑钠（SSG，Pentoclutamine）和葡甲胺锑酸盐（MA，Glucantime）是目前广泛应用于治疗皮肤利什曼病（CL）的两种锑剂，但其疗效尚不清楚。本研究的目的是比较病灶内SSG与病灶内MA治疗CL的疗效。治疗完成后1个月，1728例接受病灶内MA的患者中有1431例（82%）显示完全临床治愈，而SSG组1728例患者中有1157例（67%）。对第一轮治疗没有反应的患者重新给予相同的治疗，但每周注射两次。在完成第二个疗程后，MA组297例患者中的237例（80%）和SSG组561例患者中的407例（72%）在治疗后1个月内愈合了病变。在两个时间点，MA组和SSG组之间的治愈率差异具有统计学意义（p<0.05）。MA组的治愈率始终显著高于SSG组，而与其他参数（包括年龄、性别、病变部位和病变类型）无关。病灶内MA比病灶内SSG治疗CL更有效。
Sodium stibogluconate (SSG, Pentostam) and meglumine antimoniate (MA, Glucantime) are two antimonials that are widely used to treat cutaneous leishmaniasis (CL), but the relative efficacies of these treatments are not clear. The aim of this study is to compare the efficacy of intralesional SSG with intralesional MA therapy in the treatment of CL. One month after completion of the therapy, 1431 of 1728 patients (82%) who received intralesional MA showed complete clinical cure compared to 1157 of 1728 patients (67%) in the SSG group. Patients who did not respond to the first round of therapy were re-administered the same treatment but with twice weekly injections. Following completion of the second course of therapy, 237 of 297 patients (80%) in the MA group and 407 of 561 patients (72%) in the SSG group healed their lesions by 1-month post-treatment. At both times, the differences in cure rates between MA and SSG groups were statistically significant (p<0.05). Cure rates in the MA group were always significantly higher than SSG groups irrespective of other parameters including age, gender, lesion site and type of lesion. Intralesional MA is more effective than intralesional SSG in the treatment of CL.
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影响因子：
1.7
作者：
Neves, Leandro Ourives;Talhari, Anette Chrusciak;Talhari, Sinésio
通讯作者：
Talhari, Sinésio
影响因子：
10.3
作者：
Bumb, R. A.;Prasad, N.;Satoskar, A. R.
通讯作者：
Satoskar, A. R.
影响因子：
4.1
作者：
Faghihi, G;Tavakoli-kia, R
通讯作者：
Tavakoli-kia, R
影响因子：
3.6
作者：
Asilian, A;Sadeghinia, A;Momeni, A
通讯作者：
Momeni, A
DOI：
10.1590/s0037-86821999000400008
发表时间：
1999-07-01
影响因子：
2
作者：
Saldanha, A C;Romero, G A;Macedo, V de O
通讯作者：
Macedo, V de O