Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal.
Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal.
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白人血管紧张素原 235T 变异体与原发性高血压之间的关联：系统评价和方法学评估。
DOI：
10.1161/01.hyp.30.6.1331
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发表时间：
1997
期刊：
影响因子：
8.3
通讯作者：
Arya M. Sharma
中科院分区：
文献类型：
--
作者：
Regina Kunz;R. Kreutz;J. Beige;A. Distler;Arya M. Sharma
最近，血管紧张素原基因（AGT 235 T）的等位基因变异与高血压风险增加有关。然而，这一发现尚未得到所有调查人员的证实。进行荟萃分析，以检查AGT 235 T等位基因和白人高血压之间的关联，并确定有争议的结果的潜在原因。1992年至1996年期间发表的所有相关文章均通过多个来源确定。对这些研究进行了方法学评价，并提取了AGT 235 T等位基因的频率。使用Mantel-Haenszel的共同比值比（OR）估计值汇总235 T等位基因频率。使用Breslow-Day检验评估均匀性。这些研究共提供了5493例患者的数据。AGT 235 T等位基因与高血压显著相关（OR：1.20; 95% [CI]：1.11 - 1.29; P<.0001）。这种关联在有阳性家族史的研究中增加（OR：1.42; 95%CI：1.25 - 1.61，P<.0001），从转诊中心招募病例（OR：1.39; 95% CI：1.20 ~ 1.62，P<.0001），高血压程度更重（OR：1.34; 95% CI：1.22 ~ 1.47，P<.0001）。然而，所有研究中存在的方法问题引起了对偏倚和混淆的严重关切。尽管通过敏感性分析证实AGT 235 T变异体与高血压之间存在统计学显著相关性（尽管较弱），但必须谨慎解释这一发现，因为个别研究的方法学缺陷可能会使荟萃分析的结果产生偏倚。显然，更严格的方法需要应用于人类高血压遗传学的关联研究。
Recently, an allelic variant of the angiotensinogen gene (AGT 235T) has been associated with increased risk of hypertension. However, this finding has not been confirmed by all investigators. A meta-analysis was performed to examine the association between the AGT 235T-allele and hypertension in whites and to identify potential reasons for the controversial results. All relevant articles published between 1992 and 1996 were identified through multiple sources. The studies were methodologically appraised, and the frequency of the AGT 235T-allele was extracted. The 235T-allele frequency was pooled using the common odds ratio (OR) estimator by Mantel-Haenszel. Homogeneity was assessed using the Breslow-Day test. Together these studies present data on 5493 patients. The AGT 235T-allele was significantly associated with hypertension (OR: 1.20; 95% [CI]: 1.11 to 1.29; P<.0001). This association increased in studies with positive family history (OR: 1.42; 95% CI: 1.25 to 1.61, P<.0001), recruitment of cases from referral centers (OR: 1.39; 95% CI: 1.20 to 1.62, P<.0001), and more severe hypertension (OR: 1.34; 95% CI: 1.22 to 1.47, P<.0001). However, the presence of methodological problems in all studies gives rise to serious concerns regarding bias and confounding. Despite a statistically significant, albeit weak, association between the AGT 235T variant and hypertension that has been confirmed through sensitivity analysis, this finding has to be interpreted with caution, as the methodological weaknesses of the individual studies are likely to have biased the outcome of the meta-analysis. Clearly, more rigorous methods need to be applied in association studies on the genetics of human hypertension.
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影响因子：
9.8
作者：
G. Thomson
通讯作者：
G. Thomson
尼日利亚人、牙买加人和非裔美国人中肾素-血管紧张素基因的多态性。
DOI：
10.1161/01.hyp.27.3.558
发表时间：
1996
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Rotimi,C;Puras,A;Cooper,R;McFarlane-Anderson,N;Forrester,T;Ogunbiyi,O;Morrison,L;Ward,R
通讯作者：
Ward,R
DOI：
10.1001/jama.1990.03440100097014
发表时间：
1990-03
期刊：
JAMA
影响因子：
--
作者：
K. Dickersin
通讯作者：
K. Dickersin
影响因子：
15.9
作者：
Inoue, I;Nakajima, T;Lalouel, JM
通讯作者：
Lalouel, JM
影响因子：
9.8
作者：
Jeunemaitre, X;Inoue, I;Lalouel, JM
通讯作者：
Lalouel, JM