Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: data from the Heart and Soul Study.
Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: data from the Heart and Soul Study.
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DOI：
10.1016/j.ahj.2011.11.007
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发表时间：
2012-02
影响因子：
4.8
通讯作者：
Peralta, Carmen A.
中科院分区：
文献类型：
--
作者：
Dubin, Ruth;Li, Yongmei;Ix, Joachim H.;Shlipak, Michael G.;Whooley, Mary;Peralta, Carmen A.
pentaxin -3是一种炎症标志物，被认为比c反应蛋白（CRP）对血管炎症更特异性。戊曲辛-3是否与稳定型冠心病（CHD）患者的不良事件独立相关，是否与CRP独立相关，以及肾功能是否影响这些关联，目前尚不清楚。我们评估了基线戊烷素-3水平与37个月内参与心脏与灵魂研究的稳定型冠心病患者的全因死亡率、心血管事件（心肌梗死、中风或冠心病死亡）和心力衰竭事件的关系。Cox比例风险模型根据年龄、性别、种族、高血压、糖尿病、吸烟和CRP进行调整。在986名稳定型冠心病患者中，基线时log pentaxin -3每增加一个单位，全因死亡风险增加80% (HR 1.8, 95% CI 1.5 - 2.1)，心血管事件风险增加50% (HR 1.5, 95% CI 1.2-1.9)，心力衰竭风险增加80% （HR 1.8, 95% CI 1.3-2.5）。进一步调整估计的肾小球滤过率（eGFR）将这些相关性降低到死亡率的1.6(1.3 - 1.9)，心血管事件的1.3（1.0-1.6）和心力衰竭的1.5（1.1-2.1）。eGFR高于或低于60 ml/min/1.73m2的分层对这些关联没有影响（所有结果的相互作用p为>.3）。在稳定型冠心病患者中，较高的戊烷素-3浓度与全因死亡率、心血管事件和心力衰竭的风险增加相关，与全身炎症无关。调节eGFR适度地减弱了这些关联，这表明未来对戊烷素-3的研究应该根据肾功能进行调节。
Pentraxin-3 is an inflammatory marker thought to be more specific to vascular inflammation than C-reactive protein (CRP). Whether pentraxin-3 is independently associated with adverse events among persons with stable coronary heart disease (CHD), independently of CRP, and whether kidney dysfunction influences these associations, is not known. We evaluated the associations of baseline pentraxin-3 levels with all-cause mortality, cardiovascular events (myocardial infarction, stroke or CHD death), and incident heart failure during 37 months among ambulatory persons with stable CHD participating in the Heart and Soul Study. Cox proportional hazards models were adjusted for age, sex, race, hypertension, diabetes, smoking, and CRP. Among 986 persons with stable CHD, each one unit increase in log pentraxin-3 at baseline was associated with an 80% increased risk of all-cause mortality (HR 1.8, 95% CI 1.5–2.1), a 50% increased risk of cardiovascular events (HR 1.5, 95% CI, 1.2–1.9), and an 80% greater risk of incident heart failure (HR 1.8, 95% CI, 1.3–2.5). Further adjustment for estimated glomerular filtration rate (eGFR) attenuated these associations to 1.6 (1.3–1.9) for mortality, 1.3 (1.0–1.6) for cardiovascular events and 1.5 (1.1–2.1) for incident heart failure. Stratification by eGFR above or below 60 ml/min/1.73m2 did not affect these associations (p interaction >0.3 for all outcomes). Among persons with stable CHD, higher pentraxin-3 concentrations were associated with increased risk for all-cause mortality, cardiovascular events and incident heart failure independently of systemic inflammation. Adjustment for eGFR modestly attenuated these associations, suggesting that future studies of pentraxin-3 should adjust for kidney function.
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影响因子：
120.7
作者：
Redfield, MM;Jacobsen, SJ;Rodeheffer, RJ
通讯作者：
Rodeheffer, RJ
影响因子：
13.2
作者：
Stevens, Lesley A.;Coresh, Josef;Levey, Andrew S.
通讯作者：
Levey, Andrew S.
影响因子：
37.8
作者：
Salio, Monica;Chimenti, Stefano;Mantovani, Alberto
通讯作者：
Mantovani, Alberto
DOI：
10.1161/01.atv.0000015595.95497.2f
发表时间：
2002-05-01
影响因子：
8.7
作者：
Rolph, MS;Zimmer, S;Hansson, GK
通讯作者：
Hansson, GK
影响因子：
13.6
作者：
Shlipak, Michael G.;Fyr, Christina L. Wassel;Fried, Linda F.
通讯作者：
Fried, Linda F.