Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.

Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.
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DOI:
10.1016/j.atherosclerosis.2017.06.001
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发表时间:
2017-08
期刊:
影响因子:
5.3
通讯作者:
Mani A
Mani A
中科院分区:
医学2区
文献类型:
--
作者:
Masoudkabir F;Sarrafzadegan N;Gotay C;Ignaszewski A;Krahn AD;Davis MK;Franco C;Mani A

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心血管疾病(CVD)和癌症是全球死亡率和发病率的主要原因。改善其治疗和预防的战略是全球优先事项,也是世界卫生组织联合预防计划的主要重点。新出现的证据表明,可改变的风险因素,包括饮食,久坐不动的生活方式,肥胖和烟草使用是这两种疾病的发病机制的核心,并反映在共同的遗传,细胞和信号传导机制。了解这一重要的生物学重叠是至关重要的,可能有助于确定这两种疾病的新的治疗和预防策略。在这篇综述中,我们将讨论心血管疾病和癌症的共同遗传和分子因素,以及如何将常用的预防动脉粥样硬化血管疾病的策略应用于癌症预防。
Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity worldwide. Strategies to improve their treatment and prevention are global priorities and major focus of World Health Organization’s joint prevention programs. Emerging evidence suggests that modifiable risk factors including diet, sedentary lifestyle, obesity and tobacco use are central to the pathogenesis of both diseases and are reflected in common genetic, cellular, and signaling mechanisms. Understanding this important biological overlap is critical and may help identify novel therapeutic and preventative strategies for both disorders. In this review, we will discuss the shared genetic and molecular factors central to CVD and cancer and how the strategies commonly used for the prevention of atherosclerotic vascular disease can be applied to cancer prevention.
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