The FAANG Data Portal: Global, Open-Access, "FAIR", and Richly Validated Genotype to Phenotype Data for High-Quality Functional Annotation of Animal Genomes.
The FAANG Data Portal: Global, Open-Access, "FAIR", and Richly Validated Genotype to Phenotype Data for High-Quality Functional Annotation of Animal Genomes.
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DOI：
10.3389/fgene.2021.639238
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发表时间：
2021
影响因子：
3.7
通讯作者：
Flicek P
中科院分区：
文献类型：
--
作者：
Harrison PW;Sokolov A;Nayak A;Fan J;Zerbino D;Cochrane G;Flicek P
动物基因组功能注释 (FAANG) 项目是一项全球协调行动，旨在为养殖和伴侣动物基因组创建高质量的功能注释。丰富的基因组到表型资源的产生和支持信息基础设施扩大了比较基因组学的范围，并加深了对功能元件的理解。该项目还为陆地和水生动物农业界提供强大的资源，以支持改善养殖动物生产、抗病性和遗传多样性。 FAANG 数据门户 (https://data.faang.org) 确保可查找、可访问、可互操作和可重用 (FAIR) 开放访问由越来越多的 FAANG 联盟产生的丰富样本、测序和分析数据。它由欧洲分子生物学实验室欧洲生物信息学研究所 (EMBL-EBI) 的 FAANG 数据协调中心 (DCC) 开发和维护。 FAANG 项目产生一套标准化的多组学分析，并将所得数据放入一系列专门的开放数据档案中。为了确保社区可以轻松查找和访问这些数据，该门户会自动识别所有提交的 FAANG 数据并将其整理成一个易于搜索的资源。数据门户支持从多个底层档案直接下载，以便从门户本身无缝访问所有 FAANG 数据。该门户提供一系列预定义的过滤器、强大的预测搜索以及采样和分析协议目录，并自动识别与任何数据集相关的出版物。为了确保所有 FAANG 数据提交都是高质量的，该门户包括强大的上下文元数据验证和数据提交代理到底层 EMBL-EBI 档案。该门户将纳入广泛的新技术基础设施，以有效地交付和标准化 FAANG 向单细胞组学、细胞图谱、全基因组和新型表型预测模型的转变。数据门户通过支持动物基因组的高质量功能注释、开放公平的数据共享以及标准化的丰富元数据，在 FAANG 中发挥着关键作用。 DCC 开发的未来数据门户功能将支持新技术的发展，以持续改进 FAANG 项目。
The Functional Annotation of ANimal Genomes (FAANG) project is a worldwide coordinated action creating high-quality functional annotation of farmed and companion animal genomes. The generation of a rich genome-to-phenome resource and supporting informatic infrastructure advances the scope of comparative genomics and furthers the understanding of functional elements. The project also provides terrestrial and aquatic animal agriculture community powerful resources for supporting improvements to farmed animal production, disease resistance, and genetic diversity. The FAANG Data Portal (https://data.faang.org) ensures Findable, Accessible, Interoperable and Reusable (FAIR) open access to the wealth of sample, sequencing, and analysis data produced by an ever-growing number of FAANG consortia. It is developed and maintained by the FAANG Data Coordination Centre (DCC) at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI). FAANG projects produce a standardised set of multi-omic assays with resulting data placed into a range of specialised open data archives. To ensure this data is easily findable and accessible by the community, the portal automatically identifies and collates all submitted FAANG data into a single easily searchable resource. The Data Portal supports direct download from the multiple underlying archives to enable seamless access to all FAANG data from within the portal itself. The portal provides a range of predefined filters, powerful predictive search, and a catalogue of sampling and analysis protocols and automatically identifies publications associated with any dataset. To ensure all FAANG data submissions are high-quality, the portal includes powerful contextual metadata validation and data submissions brokering to the underlying EMBL-EBI archives. The portal will incorporate extensive new technical infrastructure to effectively deliver and standardise FAANG's shift to single-cellomics, cell atlases, pangenomes, and novel phenotypic prediction models. The Data Portal plays a key role for FAANG by supporting high-quality functional annotation of animal genomes, through open FAIR sharing of data, complete with standardised rich metadata. Future Data Portal features developed by the DCC will support new technological developments for continued improvement for FAANG projects.
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影响因子：
12.3
作者：
Andersson L;Archibald AL;Bottema CD;Brauning R;Burgess SC;Burt DW;Casas E;Cheng HH;Clarke L;Couldrey C;Dalrymple BP;Elsik CG;Foissac S;Giuffra E;Groenen MA;Hayes BJ;Huang LS;Khatib H;Kijas JW;Kim H;Lunney JK;McCarthy FM;McEwan JC;Moore S;Nanduri B;Notredame C;Palti Y;Plastow GS;Reecy JM;Rohrer GA;Sarropoulou E;Schmidt CJ;Silverstein J;Tellam RL;Tixier-Boichard M;Tosser-Klopp G;Tuggle CK;Vilkki J;White SN;Zhao S;Zhou H;FAANG Consortium
通讯作者：
FAANG Consortium
影响因子：
7.7
作者：
Regev, Aviv;Teichmann, Sarah A;Yosef, Nir
通讯作者：
Yosef, Nir
影响因子：
2.4
作者：
Tuggle, Christopher K.;Giuffra, Elisabetta;Watson, Mick
通讯作者：
Watson, Mick
影响因子：
14.9
作者：
Amid, Clara;Alako, Blaise T. F.;Cochrane, Guy
通讯作者：
Cochrane, Guy
影响因子：
9.8
作者：
Wilkinson MD;Dumontier M;Aalbersberg IJ;Appleton G;Axton M;Baak A;Blomberg N;Boiten JW;da Silva Santos LB;Bourne PE;Bouwman J;Brookes AJ;Clark T;Crosas M;Dillo I;Dumon O;Edmunds S;Evelo CT;Finkers R;Gonzalez-Beltran A;Gray AJ;Groth P;Goble C;Grethe JS;Heringa J;'t Hoen PA;Hooft R;Kuhn T;Kok R;Kok J;Lusher SJ;Martone ME;Mons A;Packer AL;Persson B;Rocca-Serra P;Roos M;van Schaik R;Sansone SA;Schultes E;Sengstag T;Slater T;Strawn G;Swertz MA;Thompson M;van der Lei J;van Mulligen E;Velterop J;Waagmeester A;Wittenburg P;Wolstencroft K;Zhao J;Mons B
通讯作者：
Mons B