A microRNA expression and regulatory element activity atlas of the mouse immune system.
A microRNA expression and regulatory element activity atlas of the mouse immune system.
复制标题
DOI：
10.1038/s41590-021-00944-y
复制
发表时间：
2021-07
影响因子：
30.5
通讯作者：
Immunological Genome Consortium
中科院分区：
文献类型：
--
作者：
Rose SA;Wroblewska A;Dhainaut M;Yoshida H;Shaffer JM;Bektesevic A;Ben-Zvi B;Rhoads A;Kim EY;Yu B;Lavin Y;Merad M;Buenrostro JD;Brown BD;Immunological Genome Consortium
To better define control of immune system regulation, we generated an atlas of microRNA (miRNA) expression from 63 mouse immune cell populations and connected these signatures with ATAC-seq, ChIP-seq and nascent RNA profiles to establish a map of miRNA promoter and enhancer usage in immune cells. miRNA complexity was relatively low, with >90% of the miRNA compartment of each population comprised of <75 miRNAs, however, each cell type had a unique miRNA signature. Integration of miRNA expression with chromatin accessibility revealed putative regulatory elements for differentially expressed miRNAs, including miR-21a, miR-146a, and miR-223. The integrated maps suggest many miRNAs utilize multiple promoters to reach high abundance, and identified dominant and divergent miRNA regulatory elements between lineages and during development, which may be used by clustered miRNAs, such as miR-99a/let-7c/miR-125b, to achieve distinct expression. These studies, with web-accessible data, help delineate the cis-regulatory elements controlling miRNA signatures of the immune system.
登录
查看更多内容
影响因子：
30.5
作者：
Agudo, Judith;Ruzo, Albert;Tung, Navpreet;Salmon, Helene;Leboeuf, Marylene;Hashimoto, Daigo;Becker, Christian;Garrett-Sinha, Lee-Ann;Baccarini, Alessia;Merad, Miriam;Brown, Brian D.
通讯作者：
Brown, Brian D.
影响因子：
16
作者：
Bosson, Andrew D.;Zamudio, Jesse R.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.
影响因子：
7
作者：
Harrow J;Frankish A;Gonzalez JM;Tapanari E;Diekhans M;Kokocinski F;Aken BL;Barrell D;Zadissa A;Searle S;Barnes I;Bignell A;Boychenko V;Hunt T;Kay M;Mukherjee G;Rajan J;Despacio-Reyes G;Saunders G;Steward C;Harte R;Lin M;Howald C;Tanzer A;Derrien T;Chrast J;Walters N;Balasubramanian S;Pei B;Tress M;Rodriguez JM;Ezkurdia I;van Baren J;Brent M;Haussler D;Kellis M;Valencia A;Reymond A;Gerstein M;Guigó R;Hubbard TJ
通讯作者：
Hubbard TJ
影响因子：
10.5
作者：
Emmrich S;Rasche M;Schöning J;Reimer C;Keihani S;Maroz A;Xie Y;Li Z;Schambach A;Reinhardt D;Klusmann JH
通讯作者：
Klusmann JH
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y