Quercetin and cancer chemoprevention.
Quercetin and cancer chemoprevention.
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DOI：
10.1093/ecam/neq053
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Cossarizza A
中科院分区：
文献类型：
--
作者：
Gibellini L;Pinti M;Nasi M;Montagna JP;De Biasi S;Roat E;Bertoncelli L;Cooper EL;Cossarizza A
饮食中存在的几种分子，包括类黄酮，可以抑制癌细胞的生长，具有“化学预防”的能力。它们的癌症预防作用归因于多种机制，包括诱导细胞周期停滞和/或凋亡以及抗氧化功能。化学预防剂的抗氧化活性最近受到了极大的关注，主要是因为氧化应激参与了不同病理条件（包括癌症）的启动和进展。由于抗氧化剂能够防止氧化损伤，广泛使用的天然食品来源的抗氧化剂作为潜在的抗癌物质正受到越来越多的关注。在黄酮类化合物中，槲皮素（Qu）被认为是一种优秀的自由基清除抗氧化剂，即使这种活性强烈依赖于细胞内还原型谷胱甘肽的可用性。除了抗氧化活性，Qu还在肿瘤细胞中发挥直接的促凋亡作用，并且确实可以在细胞周期的不同阶段阻断几种人类癌细胞系的生长。这两种效应已在多种细胞模型以及动物模型中得到证实。Qu对癌细胞的高毒性与正常非转化细胞几乎完全没有任何损伤完全匹配。在这篇综述中，我们讨论了基于Qu的生物学效应的分子机制，以及它们与人类健康的相关性。
Several molecules present in the diet, including flavonoids, can inhibit the growth of cancer cells with an ability to act as “chemopreventers”. Their cancer-preventive effects have been attributed to various mechanisms, including the induction of cell-cycle arrest and/or apoptosis as well as the antioxidant functions. The antioxidant activity of chemopreventers has recently received a great interest, essentially because oxidative stress participates in the initiation and progression of different pathological conditions, including cancer. Since antioxidants are capable of preventing oxidative damage, the wide use of natural food-derived antioxidants is receiving greater attention as potential anti-carcinogens. Among flavonoids, quercetin (Qu) is considered an excellent free-radical scavenging antioxidant, even if such an activity strongly depends on the intracellular availability of reduced glutathione. Apart from antioxidant activity, Qu also exerts a direct, pro-apoptotic effect in tumor cells, and can indeed block the growth of several human cancer cell lines at different phases of the cell cycle. Both these effects have been documented in a wide variety of cellular models as well as in animal models. The high toxicity exerted by Qu on cancer cells perfectly matches with the almost total absence of any damages for normal, non-transformed cells. In this review we discuss the molecular mechanisms that are based on the biological effects of Qu, and their relevance for human health.
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影响因子：
3.8
作者：
Bosetti, Cristina;Rossi, Marta;LaVecchia, Carlo
通讯作者：
LaVecchia, Carlo
影响因子：
6
作者：
Arnold, Rebecca S.;He, Ju;Petros, John A.
通讯作者：
Petros, John A.
影响因子：
2.8
作者：
Chien, Su-Yu;Wu, Yao-Chung;Chen, Dar-Ren
通讯作者：
Chen, Dar-Ren
影响因子：
4.3
作者：
Anderson, Lesley A.;Watson, R. G. Peter;Murray, Liam J.
通讯作者：
Murray, Liam J.
DOI：
10.1016/j.bbrc.2005.10.031
发表时间：
2005-12-16
影响因子：
3.1
作者：
Boots, AW;Balk, JM;Haenen, GRMM
通讯作者：
Haenen, GRMM