Examining the relationship of concurrent obesity and tobacco use disorder on the development of substance use disorders and psychiatric conditions: Findings from the NESARC-III.
Examining the relationship of concurrent obesity and tobacco use disorder on the development of substance use disorders and psychiatric conditions: Findings from the NESARC-III.
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检查并发肥胖和烟草使用障碍与物质使用障碍和精神疾病发展的关系：NESARC-III 的发现。
DOI：
10.1016/j.dadr.2023.100162
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发表时间：
2023-06
期刊：
影响因子：
--
通讯作者：
McKee, S A
中科院分区：
文献类型：
--
作者：
Fields, L J;Roberts, W;Schwing, I;McCoy, M;Verplaetse, T L;Peltier, M R;Carretta, R F;Zakiniaeiz, Y;Rosenheck, R;McKee, S A
我们检查了患有 TUD、肥胖以及这两种健康状况的人群中 SUD 和精神疾病的发生率。在正常体重范围内，患有 TUD 和肥胖的人的 SUD 发生率低于患有 TUD 的人。肥胖（BMI>30）与较低的 SUD 风险相关。与单一健康状况相比，多重发病与更糟糕的健康结果相关。然而，最近的研究表明，肥胖可能会降低患物质使用障碍（SUD）的风险，特别是在弱势群体中。我们调查了肥胖和烟草使用障碍 (TUD) 共病与 SUD 和精神疾病风险的关系。使用的数据来自完成全国酒精及相关病症流行病学调查 - 第三波的 36,309 人。去年符合 DSM-5 TUD 标准的个人被定义为 TUD 组。肥胖被定义为体重指数 (BMI) 大于 30 kg/m2。利用这些信息，将个体分为几类，将人们确定为患有肥胖、TUD、同时肥胖和 TUD 或既不肥胖也不患有 TUD（比较）。将各组与其他 SUD 或精神疾病的共病诊断进行比较。控制人口特征后，我们发现肥胖个体（包括 TUD 个体）的共病 SUD 诊断率低于仅患有 TUD 个体。此外，同时患有 TUD 和肥胖症的个体以及仅患有 TUD 的个体，共病精神疾病诊断率最高。目前的研究与之前的研究一致，表明肥胖可能会降低物质使用障碍的风险，即使对于具有促进有害物质使用（例如吸烟）的其他危险因素的个体也是如此。这些发现可能为该临床相关亚群的有针对性的干预策略提供信息。
We examined rates of SUD and psychiatric disorders in people with TUD, obesity, and both health conditions. People with TUD and obesity have lower rates of SUD than people with TUD in the normal weight range. Obesity (BMI>30) is associated with lower risk of SUD. Multimorbidity is linked to worse health outcomes than single health conditions. However, recent studies show that obesity may reduce the risk of developing substance use disorders (SUDs), particularly in vulnerable populations. We investigated how comorbid obesity and tobacco use disorder (TUD) relate to the risk of SUDs and psychiatric conditions. Data was used from 36,309 individuals who completed the National Epidemiological Survey on Alcohol and Related Conditions - Wave III. Individuals who met the DSM-5 criteria for TUD in the last year were defined as the TUD group. Obesity was defined as having a body mass index (BMI) greater than 30 kg/m2. Using this information, individuals were grouped into categories, with people being identified as either having obesity, TUD, both obesity and TUD, or not having either obesity or TUD (comparison). Groups were compared against their comorbid diagnoses of either an additional SUD or psychiatric conditions. Controlling for demographic characteristics, we found that individuals with obesity including those individuals with TUD, had lower rates of comorbid SUD diagnosis than individuals with TUD alone. Additionally, individuals with combined TUD and obesity, and those with TUD alone, had the highest rates of comorbid psychiatric disorder diagnosis. The current study aligns with previous research suggesting that obesity may reduce risk of substance use disorders, even in individuals who have other risk factors promoting harmful substance use (e.g., tobacco use). These findings may inform targeted intervention strategies for this clinically relevant subpopulation.
影响因子：
3.1
作者：
Chatkin R;Mottin CC;Chatkin JM
通讯作者：
Chatkin JM
一直以下乌龟：流行病学观察的生物学机制总是很重要吗？
影响因子：
13.6
作者：
Buis DTP;van Roosmalen J
通讯作者：
van Roosmalen J
影响因子：
2.2
作者：
Roberts W;Rosenheck RA
通讯作者：
Rosenheck RA