Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice.
Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice.
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DOI：
10.4162/nrp.2012.6.3.201
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发表时间：
2012-06
影响因子：
2.4
通讯作者：
Kim JI
中科院分区：
文献类型：
--
作者：
Jeong SM;Kang MJ;Choi HN;Kim JH;Kim JI
本研究探讨了槲皮素在2型糖尿病动物模型中的降糖、降血脂和抗氧化作用。4周龄C57BL/KsJ-db/db小鼠（n = 18）在适应1周后，连续6周饲喂AIN-93G日粮或含有0.04%（低槲皮素，LQE）或0.08%（高槲皮素，HQE）的日粮。测定血浆葡萄糖、胰岛素、脂联素、脂质谱和肝脏脂质过氧化。LQE组血糖水平明显低于对照组，HQE组血糖水平比LQE组进一步降低。胰岛素抵抗的稳态模型评估（HOMA-IR）显示，LQE和HQE的值低于对照组，对胰岛素水平没有显著影响。与对照组相比，高槲皮素使血浆脂联素增加。LQE组和HQE组血浆甘油三酯均低于对照组。与对照组相比，补充高槲皮素可降低血浆总胆固醇并增加高密度脂蛋白胆固醇。低和高槲皮素的消耗降低了肝脏中硫代巴比妥酸活性物质（TBARS）的水平，并提高了超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）的活性。因此，槲皮素可以有效改善2型糖尿病患者的高血糖、血脂异常和抗氧化状态。
This study investigated the hypoglycemic, hypolipidemic, and antioxidant effects of dietary quercetin in an animal model of type 2 diabetes mellitus. Four-week-old C57BL/KsJ-db/db mice (n = 18) were offered an AIN-93G diet or a diet containing quercetin at 0.04% (low quercetin, LQE) or 0.08% of the diet (high quercetin, HQE) for 6 weeks after 1 week of adaptation. Plasma glucose, insulin, adiponectin, and lipid profiles, and lipid peroxidation of the liver were determined. Plasma glucose levels were significantly lower in the LQE group than in the control group, and those in the HQE group were even further reduced compared with the LQE group. The homeostasis model assessment for insulin resistance (HOMA-IR) showed lower values for LQE and HQE than for the control group without significant influence on insulin levels. High quercetin increased plasma adiponectin compared with the control group. Plasma triglycerides in the LQE and HQE groups were lower than those in the control group. Supplementation with high quercetin decreased plasma total cholesterol and increased HDL-cholesterol compared with the control group. Consumption of low and high quercetin reduced thiobarbituric acid reactive substances (TBARS) levels and elevated activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the liver. Thus, quercetin could be effective in improving hyperglycemia, dyslipidemia, and antioxidant status in type 2 diabetes.
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影响因子：
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