Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling.
Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling.
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DOI：
10.1016/j.matbio.2017.10.007
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Vlodavsky I
中科院分区：
文献类型：
--
作者：
Sanderson RD;Bandari SK;Vlodavsky I
外泌体生物学领域的出现为更好地理解细胞之间的通信打开了一扇令人兴奋的大门。这些微小的纳米囊泡通过将蛋白质、脂质和核酸从起源细胞递送到靶细胞来充当生物功能的有效调节剂。近年来，包括膜型1基质金属蛋白酶（MT 1-MMP）、胰岛素降解酶（IDE）、唾液酸酶和乙酰肝素酶等在内的几种酶被定位于由各种细胞类型分泌的外泌体的表面。这些外泌体表面酶保留它们的活性，并且可以降解它们存在于细胞外空间内的天然底物。迄今为止，外泌体表面上的酶已经与生长因子的动员、细胞外基质大分子的降解和淀粉样蛋白β斑块的破坏相关。本文综述了外泌体表面酶的新作用，以及这种细胞外空间重塑机制如何调节与癌症、炎症和阿尔茨海默病相关的疾病进展。
Emergence of the field of exosome biology has opened an exciting door to better understanding communication between cells. These tiny nanovesicles act as potent regulators of biological function by delivering proteins, lipids and nucleic acids from the cell of origin to target cells. Recently, several enzymes including membrane-type 1 matrix metalloproteinase (MT1-MMP), insulin-degrading enzyme (IDE), sialidase and heparanase, among others, were localized on the surface of exosomes secreted by various cell types. These exosomal surface enzymes retain their activity and can degrade their natural substrates present within extracellular spaces. To date, enzymes on exosome surfaces have been associated with the mobilization of growth factors, degradation of extracellular matrix macromolecules and destruction of amyloid β plaques. This review focuses on the emerging role of exosomal surface enzymes and how this mechanism of remodeling within the extracellular space may regulate disease progression as related to cancer, inflammation and Alzheimer’s disease.
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影响因子：
4
作者：
Hakulinen, Juha;Sankkila, Lotta;Keski-Oja, Jorma
通讯作者：
Keski-Oja, Jorma
DOI：
10.3109/10409231003628015
发表时间：
2010-04
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Gooz M
影响因子：
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Sanderson, Ralph D.
DOI：
10.1073/pnas.0230450100
发表时间：
2003-04-01
影响因子：
11.1
作者：
Farris, W;Mansourian, S;Guénette, S
通讯作者：
Guénette, S
DOI：
10.1073/pnas.1304266110
发表时间：
2013-10-22
影响因子：
11.1
作者：
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通讯作者：
Belting, Mattias