Antimicrobial activities of amphiphilic cationic polymers and their efficacy of combination with novobiocin
Antimicrobial activities of amphiphilic cationic polymers and their efficacy of combination with novobiocin
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两亲性阳离子聚合物的抗菌活性及其与新生霉素联合使用的效果
DOI：
10.1080/09205063.2021.1985243
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Hatsuo Yamamura
中科院分区：
文献类型：
--
作者：
Atsushi Miyagawa;Shinya Ohno;Tomohiko Hattori;Hatsuo Yamamura
今天，耐药细菌代表了世界范围内的一个重大问题。事实上，细菌甚至对新开发的抗生素也产生了抗药性。因此，迫切需要开发细菌不能产生耐药性的抗生素。本研究以6-氨基己基甲基丙烯酰胺和N-异丙基丙烯酰胺为原料，制备了细菌不能产生耐药性的抗菌聚合物。分子量在105数量级的聚合物对金黄色葡萄球菌和大肠杆菌的抗菌活性很低，毒性也很低。另一方面，具有较低分子量（104的量级）的聚合物确实显示出对S的抗微生物活性。aureusandE.杆菌将这些聚合物与新生霉素组合以研究组合使用对E的影响。杆菌新生霉素与低分子量聚合物的联合使用降低了对E的最小抑制浓度，其小于0.0625 μ g/mL。杆菌这一结果表明，该组合可用于增加抗生素的功效并拓宽其抗菌谱。此外，结果表明，抗微生物聚合物不仅可以作为细菌尚未产生耐药性的抗生素，还可以作为其他抗生素的佐剂。
Today, drug-resistant bacteria represent a significant problem worldwide. In fact, bacteria are becoming resistant even to newly developed antibiotics. Therefore, there is an urgent need to develop antibiotics to which bacteria cannot become resistant. In this study, antimicrobial polymers to which bacteria cannot develop resistance were prepared from 6-aminohexyl methacrylamide andN-isopropyl acrylamide. The polymers with molecular weights of the order of 105showed little antimicrobial activity againstStaphylococcus aureusandEscherichia colias well as low toxicity. On the other hand, polymers with lower molecular weights (of the order of 104) did show antimicrobial activity againstS. aureusandE. coli. These polymers were combined with novobiocin to investigate the combined usage effects againstE. coli. The combined usage of novobiocin and the low-molecular-weight polymers reduced the minimum inhibitory concentration, which was less than 0.0625 μg/mL againstE. coli. This result indicates that the combination is useful for increasing the efficacy of antibiotics and broadening their antimicrobial spectrum. Furthermore, the results showed the possibility that the antimicrobial polymers serve not only as antibiotics to which bacteria have not developed resistance but also as adjuvants for other antibiotics.
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影响因子：
15
作者：
Brezden A;Mohamed MF;Nepal M;Harwood JS;Kuriakose J;Seleem MN;Chmielewski J
通讯作者：
Chmielewski J
自质体形成过程中金黄色葡萄球菌磷脂组成的变化。
DOI：
10.1016/0005-2760(80)90221-0
发表时间：
1980
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Akinobu Okabe;Yoshikazu Hirai;Hideo Hayashi;Yasuhiro Kanemasa
通讯作者：
Yasuhiro Kanemasa
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DOI：
--
发表时间：
2010
期刊：
Bioorganic & Medicinal Chemistry 20
影响因子：
--
作者：
H.Urakawa;K.Yamada;et al.
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et al.
短杆菌肽 S 启发的抗菌环糊精可破坏革兰氏阴性和革兰氏阳性细菌膜。
影响因子：
--
作者：
H. Yamamura;Kana Isshiki;Yusuke Fujita;Hisato Kato;T. Katsu;Kazufumi Masuda;Kayo Osawa;Atsushi Miyagawa
通讯作者：
Atsushi Miyagawa
影响因子：
14.2
作者：
Powers, JH
通讯作者：
Powers, JH