Bone morphogenetic protein 6 expression in oral cavity squamous cell cancer is associated with bone invasion.
Bone morphogenetic protein 6 expression in oral cavity squamous cell cancer is associated with bone invasion.
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DOI：
10.1002/lary.24267
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发表时间：
2013-12
期刊：
影响因子：
2.6
通讯作者：
Rosenthal, Eben L.
中科院分区：
文献类型：
--
作者：
Kejner, Alexandra E.;Burch, M. Benjamin;Sweeny, Larissa;Rosenthal, Eben L.
关键词：
在已知指示预后不良的生物标志物的背景下，评估口腔癌中BMP-6的骨侵袭、生存和表达。分子表达研究结合三级医疗中心相应患者的回顾性图表回顾。2000年至2009年间，197名患者接受了口腔鳞状细胞癌切除术。其中选取30例病理标本进行进一步的分子分析。根据美国癌症联合委员会（American Joint Committee on Cancer分期）和单独基于肿瘤大小的分期（TAJCC/ size）将30例患者分为三组（每组n=10）。第一组由肿瘤组成，根据肿瘤大小小于4厘米，分期为T2/2，没有骨侵犯的证据。T2/4组由基于骨侵犯而从T2转移的肿瘤组成。T4/4组包括有或无骨侵犯的大肿瘤。采用免疫组化技术检测细胞外基质金属蛋白酶诱导剂（EMMPRIN）、骨形态发生蛋白-6 （BMP-6）和表皮生长因子受体（EGFR）的表达。比较患者人口统计学、肿瘤特征、生存率和复发率。平均随访21个月。BMP-6在T2/4组（肿瘤小于4 cm且有骨侵）中的表达明显高于未发生骨侵的较大肿瘤组（T4/4组，p=0.05）。此外，在较小的肿瘤中，BMP-6表达的增加与侵袭行为相关。此外，EGFR表达升高与BMP-6水平升高呈正相关。口腔癌组织中BMP-6表达升高可能影响骨侵袭。
To evaluate bone invasion, survival, and expression of BMP-6 in oral cavity cancer in the context of known biomarkers indicative of poor prognosis. Molecular expression study combined with retrospective chart review of corresponding patients at a tertiary care center. Between 2000 and 2009, 197 patients underwent resection for oral cavity squamous cell carcinoma. Of these, 30 pathologic specimens were chosen for further molecular analysis. These 30 patients were separated into three groups (n=10 per group) based on American Joint Committee on Cancer staging and staging based on size alone (TAJCC/SIZE). The first group consisted of tumors staged as T2/2 based on size less than 4 centimeters and that had no evidence of bone invasion. The T2/4 group consisted of tumors that were upstaged from T2 based on bone invasion. The T4/4 group consisted of tumors that were large with and without bone invasion. The expression of extracellular matrix metalloproteinase inducer (EMMPRIN), bone morphogenetic protein-6 (BMP-6), and epidermal growth factor receptor (EGFR) was examined using immunohistochemistry techniques. Patient demographics, tumor characteristics, survival, and recurrence were compared. Average follow-up was 21 months. Expression of BMP-6 was significantly higher in the T2/4 cohort (tumor less than 4 centimeters with bony invasion) than the larger tumors without bone invasion (T4/4 cohort, p=0.05). Additionally, increased BMP-6 expression correlated with aggressive behavior in the smaller tumors. Furthermore, increased EGFR expression positively correlated with increased levels of BMP-6. Increased expression of BMP-6 in oral cavity cancer may affect bone invasion.
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影响因子：
4.8
作者：
Chen, YJ;Jin, YT;Wu, LW
通讯作者：
Wu, LW
DOI：
10.1186/1758-3284-2-9
发表时间：
2010-04-20
期刊：
Head & neck oncology
影响因子：
--
作者：
Jerjes W;Upile T;Petrie A;Riskalla A;Hamdoon Z;Vourvachis M;Karavidas K;Jay A;Sandison A;Thomas GJ;Kalavrezos N;Hopper C
通讯作者：
Hopper C
影响因子：
4.8
作者：
El-Hafez, Yasser G. Abd;Chen, Chien-Cheng;Yen, Tzu-Chen
通讯作者：
Yen, Tzu-Chen
影响因子：
11.2
作者：
Dai, JL;Keller, J;Keller, ET
通讯作者：
Keller, ET
影响因子：
8.8
作者：
Autzen, P;Robson, C N;Bjartell, A;Malcolm, A J;Johnson, M I;Neal, D E;Hamdy, F C
通讯作者：
Hamdy, F C