Neurobiology of nAChRs and cognition: a mini review of Dr. Jerry J. Buccafusco's contributions over a 25 year career.
Neurobiology of nAChRs and cognition: a mini review of Dr. Jerry J. Buccafusco's contributions over a 25 year career.
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DOI：
10.1016/j.bcp.2011.06.010
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发表时间：
2011-10-15
影响因子：
5.8
通讯作者：
Decker MW
中科院分区：
文献类型：
--
作者：
Terry AV Jr;Decker MW
这篇综述强调了已故博士Jerry J. Buccafusco在25年内对烟碱乙酰胆碱受体（nAChRs）和认知的神经生物学的许多贡献。这篇文章是由Buccafusco博士的两位专业同事撰写的，一位来自学术界，另一位来自制药行业。虽然Buccafusco博士在胆碱能领域的专业知识是广泛的，他对他的工作的实际意义的见解（制定新药开发战略的长期目标）是独一无二的，是基础科学界和制药公司的巨大财富。1988年，Buccafusco博士的实验室首次报告了低剂量尼古丁对非人类灵长类动物的认知增强作用。从那时起，他在啮齿动物和猴子身上研究了大量来自几个药理学类别的新型促认知剂。基于多年来对烟碱配体在体外和体内的矛盾效应的观察，Buccafusco博士提出了一个挑衅性的论点，即有可能开发出新的化学实体（具有促认知作用），这些实体能够使nAChR脱敏，而不会产生先前的激动剂作用。他最近的一些工作集中在开发作用于多个CNS靶点（包括nAChR）的单一分子实体，以增强认知，提供神经保护和/或提供额外的治疗作用（例如，抗精神病作用）。Buccafusco博士的影响力将继续存在于他多年来指导的众多研究生，博士后研究员和初级教师的工作中，这些研究生，博士后研究员和初级教师现在在世界各地担任要职。
This review highlights some of the many contributions of the late Dr. Jerry J. Buccafusco to the neurobiology of nicotinic acetylcholine receptors (nAChRs) and cognition over a 25 year period. The article is written by two of Dr. Buccafusco's professional colleagues, one from academia and one from the pharmaceutical industry. While Dr. Buccafusco's expertise in the cholinergic field was extensive, his insights into the practical relevance of his work (with a long-term goal of formulating new drug development strategies) were unique, and a great asset to both the basic science community and pharmaceutical companies. In 1988, Dr. Buccafusco's laboratory was the first to report the cognitive enhancing action of low doses of nicotine in non-human primates. Since that time he studied a large number of novel pro-cognitive agents from several pharmacological classes in rodents as well as monkeys. Based on years of observing paradoxical effects of nicotinic ligands in vitro and in vivo, Dr. Buccafusco made the provocative argument that it might be possible to develop new chemical entities (with pro-cognitive actions) that have the ability to desensitize nAChRs without producing an antecedent agonist action. Some of his more recent work focused on development of single molecular entities that act on multiple CNS targets (including nAChRs) to enhance cognition, provide neuroprotection, and/or provide additional therapeutic actions (e.g., antipsychotic effects). Dr. Buccafusco's influence will live on in the work of the numerous graduate students, postdoctoral fellows, and junior faculty that he mentored over the years who now serve in prestigious positions throughout the world.
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DOI：
10.1016/s0169-328x(99)00048-0
发表时间：
1999-04-06
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
French, SJ;Humby, T;Rattray, M
通讯作者：
Rattray, M
影响因子：
6.7
作者：
BENOWITZ, NL;JACOB, P
通讯作者：
JACOB, P
影响因子：
5.8
作者：
Buccafusco, Jerry J.;Terry, Alvin V., Jr.;Gopalakrishnan, Murali
通讯作者：
Gopalakrishnan, Murali
DOI：
10.1124/jpet.108.145292
发表时间：
2009-02-01
影响因子：
3.5
作者：
Buccafusco, Jerry J.;Beach, J. Warren;Terry, Alvin V., Jr.
通讯作者：
Terry, Alvin V., Jr.
影响因子：
3
作者：
BUCCAFUSCO, JJ;SPECTOR, S
通讯作者：
SPECTOR, S