Avian genomics lends insights into endocrine function in birds.
Avian genomics lends insights into endocrine function in birds.
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DOI：
10.1016/j.ygcen.2017.05.023
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发表时间：
2018-01-15
影响因子：
2.7
通讯作者：
Lovell PV
中科院分区：
文献类型：
--
作者：
Mello CV;Lovell PV
基因组学时代带来了沿着完成的大量鸟类基因组测序，涵盖了鸟类系统发育树的广泛范围（>30个目），导致对鸟类生物学和进化的重大新见解。在最近的发现中，考虑到许多这些基因的生理重要性，鸟类缺乏大量在其他脊椎动物中以高度保守的同线簇组织的蛋白质编码基因的发现非常有趣。它们中有相当一部分发挥着重要的内分泌作用，这表明鸟类进化出了补偿性的遗传或生理机制，使它们能够在这些损失中生存和繁荣。虽然需要进一步的研究来确定鸟类基因丢失的确切程度，但这些发现表明鸟类是潜在的高度相关的模式生物，可用于探索广泛的内分泌功能和疾病的遗传基础和可能的治疗方法。
The genomics era has brought along the completed sequencing of a large number of bird genomes that cover a broad range of the avian phylogenetic tree (>30 orders), leading to major novel insights into avian biology and evolution. Among recent findings, the discovery that birds lack a large number of protein coding genes that are organized in highly conserved syntenic clusters in other vertebrates is very intriguing, given the physiological importance of many of these genes. A considerable number of them play prominent endocrine roles, suggesting that birds evolved compensatory genetic or physiological mechanisms that allowed them to survive and thrive in spite of these losses. While further studies are needed to establish the exact extent of avian gene losses, these findings point to birds as potentially highly relevant model organisms for exploring the genetic basis and possible therapeutic approaches for a wide range of endocrine functions and disorders.
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DOI：
10.1126/science.1253451
发表时间：
2014-12-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jarvis ED;Mirarab S;Aberer AJ;Li B;Houde P;Li C;Ho SY;Faircloth BC;Nabholz B;Howard JT;Suh A;Weber CC;da Fonseca RR;Li J;Zhang F;Li H;Zhou L;Narula N;Liu L;Ganapathy G;Boussau B;Bayzid MS;Zavidovych V;Subramanian S;Gabaldón T;Capella-Gutiérrez S;Huerta-Cepas J;Rekepalli B;Munch K;Schierup M;Lindow B;Warren WC;Ray D;Green RE;Bruford MW;Zhan X;Dixon A;Li S;Li N;Huang Y;Derryberry EP;Bertelsen MF;Sheldon FH;Brumfield RT;Mello CV;Lovell PV;Wirthlin M;Schneider MP;Prosdocimi F;Samaniego JA;Vargas Velazquez AM;Alfaro-Núñez A;Campos PF;Petersen B;Sicheritz-Ponten T;Pas A;Bailey T;Scofield P;Bunce M;Lambert DM;Zhou Q;Perelman P;Driskell AC;Shapiro B;Xiong Z;Zeng Y;Liu S;Li Z;Liu B;Wu K;Xiao J;Yinqi X;Zheng Q;Zhang Y;Yang H;Wang J;Smeds L;Rheindt FE;Braun M;Fjeldsa J;Orlando L;Barker FK;Jønsson KA;Johnson W;Koepfli KP;O'Brien S;Haussler D;Ryder OA;Rahbek C;Willerslev E;Graves GR;Glenn TC;McCormack J;Burt D;Ellegren H;Alström P;Edwards SV;Stamatakis A;Mindell DP;Cracraft J;Braun EL;Warnow T;Jun W;Gilbert MT;Zhang G
通讯作者：
Zhang G
影响因子：
3.3
作者：
Carney, J. Aidan;Lyssikatos, Charalampos;Stratakis, Constantine A.
通讯作者：
Stratakis, Constantine A.
影响因子：
4.8
作者：
Friedman-Einat, Miriam;Cogburn, Larry A.;Seroussi, Eyal
通讯作者：
Seroussi, Eyal
影响因子：
7.7
作者：
Hivert, Marie-France;Manning, Alisa K.;McAteer, Jarred B.;Dupuis, Josee;Fox, Caroline S.;Cupples, L. Adrienne;Meigs, James B.;Florez, Jose C.
通讯作者：
Florez, Jose C.
影响因子：
6.2
作者：
Corsi, A;Xu, T;Young, MF
通讯作者：
Young, MF