Reduced bone density in women with fractures: Contribution of low peak bone density and rapid bone loss
Reduced bone density in women with fractures: Contribution of low peak bone density and rapid bone loss
复制标题
骨折女性骨密度降低：低峰值骨密度和快速骨质流失的影响
DOI：
10.1007/bf01623430
复制
发表时间：
2005
影响因子：
4
通讯作者：
Associate Professor E. Seeman
中科院分区：
文献类型：
--
作者：
Associate Professor E. Seeman
骨质疏松症被认为是老年人的一种疾病，因为骨折发生在生命的晚期。尽管在衰老过程中过度的骨丢失可能导致骨密度不足，但骨折患者并不总是有更快的骨丢失、更大的骨吸收或更低的骨形成(使用骨转换的生化或组织形态计量学标记物来衡量)。以骨质疏松症为特征的低骨密度和骨脆性的发病机制可能始于生命的头20年。在局部生长和矿物质积累的激素调节方面存在差异，在轴骨和附件骨、皮质骨和松质骨以及肢体近端和远端的起病年龄、线性增长的速率和持续时间以及矿物质积累方面存在差异。疾病、风险或保护性因素以及激素缺乏或过剩的紊乱可能会影响纵向生长、矿物质积累或两者兼而有之，具体取决于暴露的时间。当暴露发生在生长期间而不是成年期时，对骨密度的影响可能在数量上更大，质量上不同。这些缺陷的大小和位置很可能建立起与年龄和性激素相关的区域性骨丢失的相关性。因此，任何关于骨质疏松症流行病学和发病机制的统一假说都必须考虑成年期低峰值骨密度和骨丢失对骨密度不足的相对贡献。需要大量的研究来检验纵向生长和矿物质积累的生理学，因为骨质疏松症的发病机制至少部分是由生命最初20年发生的事件解释的。
Osteoporosis is regarded as a disease of the elderly because fractures occur late in life. Although excessive bone loss during aging is likely to contribute to the deficit in bone density, patients with fractures do not consistently have more rapid bone loss, greater bone resorption or lower bone formation (measured using biochemical or histomorphometric markers of bone turnover). The pathogenesis of the low bone density and bone fragility that characterize osteoporosis may begin during the first two decades of life. There are differences in the hormonal regulation of regional growth and mineral accrual, differences in the age of onset, rate and duration of linear growth and mineral accrual of the axial and appendicular skeleton, of cortical and trabecular bone, and of proximal and distal limb segments. Illnesses, risk or protective factors, and disorders of hormonal deficiency or excess may affect longitudinal growth, mineral accrual, or both, depending on the timing of exposure. Quantitatively larger and qualitatively different effects on bone density may result when exposure occurs during growth rather than during adulthood. The magnitude of these deficits and their location are likely to establish the relevance of regional age-related and sex hormone dependent bone loss. Thus, any unifying hypothesis concerning the epidemiology and pathogenesis of osteoporosis must consider the relative contributions of low peak bone density and bone loss to the deficit in bone density in adulthood. A great deal of research is needed to examine the physiology of longitudinal growth and mineral accrual as the pathogenesis of osteoporosis is at least partly explained by events occurring during the first 20 years of life.
钙摄入量：协变量和混杂因素。
DOI：
10.1093/ajcn/53.3.741
发表时间：
1991
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Holbrook,TL;Barrett-Connor,E
通讯作者：
Barrett-Connor,E
接受生长激素的特纳综合征青少年不会出现骨质减少。
DOI：
10.1210/jcem.76.4.8473397
发表时间：
1993
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Neely,EK;Marcus,R;Rosenfeld,RG;Bachrach,LK
通讯作者：
Bachrach,LK
影响因子：
7.1
作者：
SANDLER, RB;SLEMENDA, CW;KRISKA, AM
通讯作者：
KRISKA, AM