Application of ultrasound on monitoring the evolution of the collagen fiber reinforced nHAC/CS composites in vivo.
Application of ultrasound on monitoring the evolution of the collagen fiber reinforced nHAC/CS composites in vivo.
复制标题
应用超声监测胶原纤维增强 nHAC/CS 复合材料体内演化
DOI：
10.1155/2014/418302
复制
发表时间：
2014
影响因子：
--
通讯作者：
Yu B
中科院分区：
文献类型：
--
作者：
Chen Y;Yan Y;Li X;Li H;Tan H;Li H;Zhu Y;Niemeyer P;Yaega M;Yu B
目前，纤维增强支架已广泛应用于硬组织和软组织的修复。同时，在其广泛应用之前，对支架进行长期的体内监测被认为是一个至关重要的问题。因此，对原位和真实的实时分析植入重塑过程的非侵入性和方便的方法的需求日益增长。本文采用诊断医学超声监测由壳聚糖（CS）、纳米羟基磷灰石（nHA）和胶原纤维（Col）合成的新型矿化胶原纤维增强复合材料的体内成骨和降解过程。将大鼠骨髓间充质干细胞（rBMSCs）与支架材料复合植入SD大鼠背部，观察细胞对骨重建过程的影响。从超声图像中提取支架在体内的系统数据。B超与DXA结果有显著性差异（P < 0.05）。这表明，超声可以作为一种可行的替代无创监测支架原位细胞生长过程中的演变。
To date, fiber reinforce scaffolds have been largely applied to repair hard and soft tissues. Meanwhile, monitoring the scaffolds for long periods in vivo is recognized as a crucial issue before its wide use. As a consequence, there is a growing need for noninvasive and convenient methods to analyze the implantation remolding process in situ and in real time. In this paper, diagnostic medical ultrasound was used to monitor the in vivo bone formation and degradation process of the novel mineralized collagen fiber reinforced composite which is synthesized by chitosan (CS), nanohydroxyapatite (nHA), and collagen fiber (Col). To observe the impact of cells on bone remodeling process, the scaffolds were planted into the back of the SD rats with and without rat bone mesenchymal stem cells (rBMSCs). Systematic data of scaffolds in vivo was extracted from ultrasound images. Significant consistency between the data from the ultrasound and DXA could be observed (P < 0.05). This indicated that ultrasound may serve as a feasible alternative for noninvasive monitoring the evolution of scaffolds in situ during cell growth.
登录
查看更多内容
影响因子：
2.4
作者：
Duenwald, Sarah;Kobayashi, Hirohito;Frisch, Kayt;Lakes, Roderic;Vanderby, Ray, Jr.
通讯作者：
Vanderby, Ray, Jr.
一种骨状纳米羟基磷灰石/胶原蛋白负载的可注射支架
影响因子：
4
作者：
Huang, Zhi;Tian, Jing;Feng, Qingling
通讯作者：
Feng, Qingling
影响因子：
3.8
作者：
Deuerling, Justin M.;Rudy, David J.;Roeder, Ryan K.
通讯作者：
Roeder, Ryan K.
影响因子：
1.1
作者：
Asai, H;Kanai, H;Chubachi, N
通讯作者：
Chubachi, N
DOI：
10.1143/jjap.44.4578
发表时间：
2005-06-01
期刊：
JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS
影响因子：
--
作者：
Otani, T
通讯作者：
Otani, T