Higher levels of C-reactive protein in the acute phase of stroke indicate an increased risk for post-stroke depression: A systematic review and meta-analysis
Higher levels of C-reactive protein in the acute phase of stroke indicate an increased risk for post-stroke depression: A systematic review and meta-analysis
复制标题
中风急性期较高水平的 C 反应蛋白表明中风后抑郁症的风险增加：系统评价和荟萃分析
DOI：
10.1016/j.neubiorev.2021.08.018
复制
发表时间：
2021-08
影响因子：
8.2
通讯作者：
Shaokuan Fang
中科院分区：
文献类型：
--
作者：
Yu Yang;Lijun Zhu;Beilin Zhang;Jiguo Gao;Teng Zhao;Shaokuan Fang
研究背景研究表明炎症与卒中后抑郁（post-stroke depression，PSD）之间存在相关性。然而，是否C-反应蛋白（CRP）水平，炎症的生物标志物，会影响PSD的发展仍然存在争议。MethodsA系统检索数据库进行合格的研究。采用标准化均数差（SMD）和95%可信区间（CI）评价脑卒中急性期CRP水平与PSD风险的关系。综合结果显示，与非PSD患者相比，PSD患者入院时的CRP水平明显较高（SMD = 0.19，95%CI：0.12 - 0.27）。按抑郁评估时间分组进行亚组分析，发现卒中后1个月以上确诊的PSD患者与非PSD患者CRP水平差异有显著性（1 - 3个月：SMD = 0.16，95%CI：0.06 - 0.25; > 3个月：SMD = 0.34，95%CI：0.18 - 0.51）.结论卒中急性期CRP水平升高提示PSD风险增加。
BackgroundInvestigations have revealed the association between inflammation and post-stroke depression (PSD). However, whether the C-reactive protein (CRP) level, a biomarker of inflammation, would affect the development of PSD is still controversial.MethodsA systematic search of databases was performed for eligible studies. Standardized Mean Difference (SMD) with 95 % Confidence Interval (CI) was used to assess the association between the CRP level in the acute phase of stroke and the risk of PSD.Results13 cohort studies that involved 3536 participants were included. Combined results showed that compared with non-PSD patients, the CRP level of PSD patients was significantly higher on admission (SMD = 0.19, 95 % CI: 0.12−0.27). A subgroup analysis by classifying the assessment time of depression showed obvious differences of the CRP levels between the PSD patients who were diagnosed more than 1 month after stroke and the non-PSD (1−3 months: SMD = 0.16, 95 % CI: 0.06−0.25; >3months: SMD = 0.34, 95 % CI: 0.18−0.51).ConclusionA higher level of CRP in the acute phase of stroke suggests an increased risk for PSD.
登录
查看更多内容
影响因子：
2.9
作者：
Kocaturk, Mehtap;Kocaturk, Ozcan
通讯作者：
Kocaturk, Ozcan
影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
7.2
作者：
Kim, Jae-Min;Kang, Hee-Ju;Cho, Ki-Hyun
通讯作者：
Cho, Ki-Hyun
影响因子：
6.7
作者：
M. Pascoe;S. Crewther;L. Carey;D. Crewther
通讯作者：
M. Pascoe;S. Crewther;L. Carey;D. Crewther
影响因子：
2.5
作者：
Qian-Qian Yang-Qian;Di Shao;Jie Li;Chunlian Yang;Min-Hua Fan;F. Cao
通讯作者：
Qian-Qian Yang-Qian;Di Shao;Jie Li;Chunlian Yang;Min-Hua Fan;F. Cao