Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China.
Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China.
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中国2型糖尿病患者冠心病和脑卒中风险的性别差异及其与代谢综合征的关系
DOI：
10.1155/2016/8483405
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发表时间：
2016
影响因子：
2.8
通讯作者：
Shan PF
中科院分区：
文献类型：
--
作者：
Yao MF;He J;Sun X;Ji XL;Ding Y;Zhao YM;Lou HY;Song XX;Shan LZ;Kang YX;Zhang SZ;Shan PF
冠心病（CHD）和中风是2型糖尿病（T2DM）的常见并发症。我们的目的是探讨中国女性和男性 T2DM 患者患冠心病和中风的风险差异及其与代谢综合征 (MS) 的关系。该研究纳入了 1514 名 T2DM 患者。 MS诊断采用ATPIII亚洲指南（2005），采用UKPDS风险引擎评估10年CHD和中风风险。与男性 T2DM 患者相比，女性的 CHD 风险（15.3% vs 26.3%）、致命性 CHD 风险（11.8% vs 19.0%）、卒中风险（8.4% vs 10.3%）和致命性卒中风险（1.4% vs 1.6%）较低（p < 0.05–0.001）。患有多发性硬化症的男性的冠心病风险（28.4% 对比 22.6%，p < 0.001）显着高于未患有多发性硬化症的男性。患有多发性硬化症的女性的冠心病（16.2% 对比 11.0%，p < 0.001）和中风风险（8.9% 对比 5.8%，p < 0.001）高于未患有多发性硬化症的女性。总之，我们的研究结果表明，患有 T2DM 的中国女性比男性更不易患冠心病和中风。此外，MS 增加了这两种事件的风险，凸显了 T2DM 全面代谢控制的必要性。
Coronary heart disease (CHD) and stroke are common complications of type 2 diabetes mellitus (T2DM). We aimed to explore the differences in the risks of CHD and stroke between Chinese women and men with T2DM and their association with metabolic syndrome (MS). This study included 1514 patients with T2DM. The Asian Guidelines of ATPIII (2005) were used for MS diagnosis, and the UKPDS risk engine was used to evaluate the 10-year CHD and stroke risks. Women had lower CHD risk (15.3% versus 26.3%), fatal CHD risk (11.8% versus 19.0%), stroke risk (8.4% versus 10.3%), and fatal stroke risk (1.4% versus 1.6%) compared with men with T2DM (p < 0.05–0.001). The CHD risk (28.4% versus 22.6%, p < 0.001) was significantly higher in men with MS than in those without MS. The CHD (16.2% versus 11.0%, p < 0.001) and stroke risks (8.9% versus 5.8%, p < 0.001) were higher in women with MS than in those without MS. In conclusion, our findings indicated that Chinese women with T2DM are less susceptible to CHD and stroke than men. Further, MS increases the risk of both these events, highlighting the need for comprehensive metabolic control in T2DM.
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影响因子：
16.2
作者：
Isomaa, B;Almgren, P;Groop, L
通讯作者：
Groop, L
影响因子：
5.6
作者：
Carson, April P.;Tanner, Rikki M.;Yun, Huifeng;Glasser, Stephen P.;Woolley, J. Michael;Thacker, Evan L.;Levitan, Emily B.;Farkouh, Michael E.;Rosenson, Robert S.;Brown, Todd M.;Howard, George;Safford, Monika M.;Muntner, Paul
通讯作者：
Muntner, Paul
影响因子：
16.2
作者：
Stevens, R;Coleman, RL;Holman, RR
通讯作者：
Holman, RR
影响因子：
2.7
作者：
Zhu M;Li J;Li Z;Luo W;Dai D;Weaver SR;Stauber C;Luo R;Fu H
通讯作者：
Fu H
影响因子：
4.5
作者：
Bae, Ji Cheol;Cho, Nam H.;Lee, Moon-Kyu
通讯作者：
Lee, Moon-Kyu