New classes of environmental tumor promoters: indole alkaloids and polyacetates.
New classes of environmental tumor promoters: indole alkaloids and polyacetates.
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新一类环境肿瘤促进剂：吲哚生物碱和聚乙酸酯。
DOI：
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发表时间：
1983
影响因子：
10.4
通讯作者：
R. Moore
中科院分区：
文献类型：
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作者：
H. Fujiki;T. Sugimura;R. Moore
已知肿瘤促进剂在小鼠皮肤中诱导ODC活性，并且这种诱导可以通过应用13-顺式-视黄酸来抑制。利用肿瘤促进剂的这两个性质在我们的环境中筛选新的肿瘤促进剂。两个新的类别的肿瘤促进剂：吲哚生物碱（teleocidin和lyngbyatoxin A）和聚乙酸酯（aplasiatoxin和debromoaplasiatoxin）。来自Streptococcus的Teleocidin和来自蓝绿色真菌Lyngbya majuscula的Lyngbyatoxin A能够诱导小鼠皮肤中的ODC活性，并显示出与TPA相似的各种生物活性。Teleocidin和lyngbyatoxin A是吲哚生物碱。通过两阶段致癌性试验，它们在小鼠皮肤中的促肿瘤活性变得明显。DMBA + Teleocidin组30周时肿瘤发生率为100%，与DMBA + TPA组相似。lyngbyatoxin A的体内致癌性测试仍在进行中。用DMBA加lyngbyatoxin A处理的组的肿瘤发生率在第21周为80%。第二类新的肿瘤促进剂是聚乙酸酯。从另一种蓝绿色植物中分离出了阿氏藻毒素和脱溴阿氏藻毒素。阿贝氏毒素和脱溴阿贝氏毒素诱导ODC的效力相同。然而，在TPA、杀鱼素和lyngbyatoxin A浓度相近的情况下，阿氏藻毒素可诱导多种膜效应，如细胞粘附和磷脂周转。另一方面，去溴黄曲霉毒素需要几乎100倍的量才能达到同样的效果。我们相信在我们的环境中存在各种类型的肿瘤促进剂的可能性。
Tumor promoters are known to induce ODC activity in mouse skin and that this induction can be inhibited by the application of 13-cis-retinoic acid. These two properties of tumor promoters were utilized for screening new tumor promoters in our environment. Two new classes of tumor promoters are presented: indole alkaloids (teleocidin and lyngbyatoxin A) and polyacetates (aplysiatoxin and debromoaplysiatoxin). Teleocidin from streptomyces and lyngbyatoxin A, from the blue-green alga, Lyngbya majuscula, were able to induce ODC activity in mouse skin and showed various biological activities similar to those of TPA. Teleocidin and lyngbyatoxin A are indole alkaloids. Their tumor promoting activities became apparent in the mouse skin through a two-stage carcinogenicity test. The tumor incidence of the group treated with DMBA plus teleocidin was 100% at week 30, which was similar to that of the group given DMBA and TPA. The in vivo carcinogenicity test with lyngbyatoxin A is still underway. The tumor incidence of the group treated with DMBA plus lyngbyatoxin A is 80% at week 21. A second new class of tumor promoter is polyacetate. Aplysiatoxin and debromoaplysiatoxin were isolated from another variety of blue-green alga. Aplysiatoxin and debromoaplysiatoxin induce ODC to the same degree of potency. However, aplysiatoxin induced various membrane effects, such as adhesion of cells and turnover of phospholipid with a similar concentration of TPA, teleocidin and lyngbyatoxin A. On the other hand, debromoaplysiatoxin required an amount almost 100 times greater to achieve the same effects. We are convinced of the possibility that various classes of tumor promoters exist in our environment.
海螺毒素、去溴海螺毒素和远杀素对受体结合和磷脂代谢的影响比较。
影响因子：
11.2
作者：
Horowitz,AD;Fujiki,H;Weinstein,IB;Jeffrey,A;Okin,E;Moore,RE;Sugimura,T
通讯作者：
Sugimura,T
肿瘤促进剂刺激人多形核白细胞超氧阴离子自由基的产生。
影响因子：
9.7
作者：
Goldstein,BD;Witz,G;Amoruso,M;Stone,DS;Troll,W
通讯作者：
Troll,W
通过重复 12-o-十四烷酰佛波醇-13-乙酸酯处理来超诱导小鼠表皮鸟氨酸脱羧酶活性。
影响因子：
4.3
作者：
Verma,AK;Hsiao,KM;Ahrens,H;Suganuma,M;Fujiki,H;Matsufuji,S;Hayashi,H
通讯作者：
Hayashi,H