Interactions between heparan sulfate and proteins: the concept of specificity.

Interactions between heparan sulfate and proteins: the concept of specificity.
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硫酸乙酰肝素与蛋白质之间的相互作用:特异性的概念。

DOI:
10.1083/jcb.200604035
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发表时间:
2006-07-31
影响因子:
7.8
通讯作者:
Lindahl, Ulf
Lindahl, Ulf
中科院分区:
生物学1区
文献类型:
--
作者:
Kreuger, Johan;Spillmann, Dorothe;Li, Jin-ping;Lindahl, Ulf

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蛋白多糖(PG)辅受体携带硫酸乙酰肝素(HS)链,介导与生长因子、形态因子和受体的相互作用。因此,前列腺素调节细胞存活、分裂、黏附、迁移和分化等基本过程。这篇综述总结了最新的生化和遗传信息,为HS蛋白结合的性质提供了新的线索。出乎意料的是,许多相互作用似乎更多地依赖于HS域的整体组织,而不是它们的精细结构。
Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS–protein binding. Unexpectedly, many interactions appear to depend more on the overall organization of HS domains than on their fine structure.
DOI: 10.1083/jcb.200212083
发表时间: 2003-07-21
影响因子: 7.8
作者:
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期刊: DEVELOPMENTAL CELL
影响因子: 11.8
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发表时间: 1996-07-26
影响因子: 4.8
作者:
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DOI: 10.1074/jbc.273.36.22936
发表时间: 1998-09-04
影响因子: 4.8
作者:
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通讯作者: Gallagher, JT