Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications.

Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications.
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DOI:
10.1111/j.1365-2559.2009.03454.x
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发表时间:
2010-01
期刊:
影响因子:
6.4
通讯作者:
Lazar AJ
Lazar AJ
中科院分区:
医学2区
文献类型:
--
作者:
Shalin SC;Lyle S;Calonje E;Lazar AJ

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皮脂腺瘤形成包括从良性到恶性的范围。正确的组织学鉴定对于治疗、预后以及与 Muir-Torre 综合征 (MTS) 的潜在关联非常重要。我们对这些肿瘤的重要性和发病机制的了解不断加深,从而改进了风险分层、筛查建议以及对初次出现皮脂腺肿瘤的患者的治疗。本综述重点关注皮脂腺病变、MTS 的诊断和组织学特征,以及对皮脂腺肿瘤发生的分子发病机制的最新见解。
Sebaceous neoplasia comprises a spectrum ranging from benign to malignant. Proper histological identification is important for treatment, prognosis and potential association with the Muir–Torre syndrome (MTS). Our increased understanding of the significance and pathogenesis of these tumours has led to improved risk stratification, screening recommendations, and treatment of patients with an initial presentation of a sebaceous tumour. This review focuses on the diagnostic and histological features of sebaceous lesions, the MTS, and recent insights into the molecular pathogenesis of sebaceous tumorigenesis.
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