Influence of blood pressure, heart rate, age, and sex on concentrations of atrial natriuretic factor and cyclic GMP in 124 volunteers.
Influence of blood pressure, heart rate, age, and sex on concentrations of atrial natriuretic factor and cyclic GMP in 124 volunteers.
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124 名志愿者的血压、心率、年龄和性别对心房钠尿因子和环 GMP 浓度的影响。
DOI：
10.1093/clinchem/35.7.1519
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发表时间：
1989
影响因子：
9.3
通讯作者：
B. Puschendorf
中科院分区：
文献类型：
--
作者：
M. Wencker;S. Hauptlorenz;W. Moll;B. Puschendorf
心钠素（ANF）升高与血压和年龄的关系的意义仍有争议。我们研究了血压、年龄和其他变量对心钠素及其第二信使cGMP的影响。ANF和cGMP检测样本取自124名献血的表面健康个体。还从27名志愿者献血前后采集样本，以研究出血的影响。献血期间，ANF从78.9增加到87.4 ng/L（P = 0.0035），而cGMP保持不变。124名健康个体的ANF浓度，校正出血的影响，为61.5（SD 26.1）ng/L，95%置信区间为10.0至112.1 ng/L。血浆中的平均cGMP浓度为2.9（SD 1.45）nmol/L，95%置信区间为0.4 - 5.75 nmol/L。多变量分析显示血压、年龄、心率或性别对血浆中ANF或cGMP浓度无显著影响。
The significance of increased atrial natriuretic factor (ANF) in relation to blood pressure and age is still controversial. We investigated the influence of blood pressure, age, and some other variables on ANF and its putative second messenger, cGMP. Samples for ANF and cGMP detection were taken from 124 ostensibly healthy individuals who were donating blood. Samples were also collected from 27 volunteers before and after blood donation, to study the influence of bleeding. During blood donation, ANF increased from 78.9 to 87.4 ng/L (P = 0.0035), whereas cGMP remained unchanged. ANF concentrations in 124 healthy individuals, corrected for the influence of bleeding, were 61.5 (SD 26.1) ng/L, with a 95% confidence interval of 10.0 to 112.1 ng/L. Mean cGMP concentrations in plasma were 2.9 (SD 1.45) nmol/L, with a 95% confidence interval of 0.4 to 5.75 nmol/L. Multivariance analysis revealed no significant influence of blood pressure, age, heart rate, or sex on concentrations of either ANF or cGMP in plasma.
人体免疫反应性心房钠尿激素血浆水平与血流动力学功能之间的关系。
影响因子：
37.8
作者：
Bates,ER;Shenker,Y;Grekin,RJ
通讯作者：
Grekin,RJ