Effect of hypoxia on excitatory transmission in the rat substantia gelatinosa neurons.
Effect of hypoxia on excitatory transmission in the rat substantia gelatinosa neurons.
复制标题
缺氧对大鼠胶质质神经元兴奋性传递的影响。
DOI：
10.1016/s0006-291x(02)00790-8
复制
发表时间：
2002
影响因子：
3.1
通讯作者：
Jun Kim
中科院分区：
文献类型：
--
作者：
Yun Kyung Park;Sung Jun Jung;Jiyeon Kwak;Jun Kim
We have investigated the effect of hypoxia on the excitatory synaptic transmission in the substantia gelatinosa neurons using perforated-patch-clamp configuration. Brief periods of hypoxia induced a depression in the evoked excitatory postsynaptic current (eEPSC) amplitude. The hypoxia-induced depression of eEPSC was not observed in the presence of theophylline, a nonselective adenosine receptor antagonist, and DPCPX, a selective adenosine receptor A1antagonist. Application of adenosine (100 μM ) also depressed eEPSC in a similar way as with hypoxia. This adenosine-induced depression of eEPSC was inhibited by DPCPX. Hypoxia and exogenous adenosine decreased the frequency of the spontaneous excitatory postsynaptic current (sEPSC) but not the amplitude of sEPSC and increased the paired-pulse ratio. From these results, it is suggested that acute hypoxia depresses the excitatory synaptic transmission by activating the presynaptic adenosine A1receptor.
DOI：
--
发表时间：
1988-11
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
J. Choca;Richard D. Green;Herbert K. Proudfit
通讯作者：
J. Choca;Richard D. Green;Herbert K. Proudfit
影响因子：
21.1
作者：
B. Fredholm;K. Bättig;J. Holmén;A. Nehlig;E. Zvartau
通讯作者：
B. Fredholm;K. Bättig;J. Holmén;A. Nehlig;E. Zvartau
影响因子：
--
作者：
REPPERT, SM;WEAVER, DR;RIVKEES, SA
通讯作者：
RIVKEES, SA