Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort.
Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort.
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DOI：
10.1002/oby.23178
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Khunti K
中科院分区：
文献类型：
--
作者：
Yates T;Zaccardi F;Islam N;Razieh C;Gillies CL;Lawson CA;Chudasama Y;Rowlands A;Davies MJ;Docherty AB;Openshaw PJM;Baillie JK;Semple MG;ISARIC4C investigators;Khunti K
本研究的目的是调查不同种族群体中肥胖与 2019 年冠状病毒病 (COVID-19) 住院结果的关联。根据国际严重急性呼吸系统和新发感染联盟 (ISARIC) 制定的英国临床特征分析方案 (CCP-UK)，纳入了 2020 年 2 月 6 日至 10 月 12 日期间在英国住院的 COVID-19 患者。种族分为白人、南亚裔、黑人和其他少数族裔。结果包括接受重症监护、机械通气和院内死亡率，并根据年龄、性别和慢性疾病进行调整。在参与者中，54,254 名（年龄 = 76 岁；45.0% 女性）为白人，3,728 名（57 岁；41.1% 女性）为南亚裔，2,523 名（58 岁；44.9% 女性）为黑人，5,427 名（61 岁；40.8% 女性）为其他种族。肥胖与所有种族的所有结果相关，其中黑人种族的相关性最强。按种族和肥胖状况分层时，与没有肥胖的白人相比，肥胖黑人接受重症监护、机械通气和死亡率的比值比分别为 3.91 (3.13-4.88)、5.03 (3.94-6.63) 和 1.93 (1.49-2.51)。在所有种族中，肥胖都与院内 COVID-19 结局风险升高相关，其中黑人种族的相关性最强。
The aim of this study was to investigate the association of obesity with in‐hospital coronavirus disease 2019 (COVID‐19) outcomes in different ethnic groups. Patients admitted to hospital with COVID‐19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP‐UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in‐hospital mortality, adjusted for age, sex, and chronic diseases. Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13‐4.88), 5.03 (3.94‐6.63), and 1.93 (1.49‐2.51), respectively, compared with White ethnicities without obesity. Obesity was associated with an elevated risk of in‐hospital COVID‐19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.
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