Recurrent polymorphonuclear pleocytosis with increased red blood cells caused by varicella zoster virus infection of the central nervous system: Case report and review of the literature.
Recurrent polymorphonuclear pleocytosis with increased red blood cells caused by varicella zoster virus infection of the central nervous system: Case report and review of the literature.
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DOI：
10.1016/j.jns.2010.01.019
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发表时间：
2010-05-15
影响因子：
4.4
通讯作者：
Gilden, Don
中科院分区：
文献类型：
--
作者：
Haug, Aaron;Mahalingam, Ravi;Cohrs, Randall J.;Schmid, D. Scott;Corboy, John R.;Gilden, Don
我们描述了一位免疫功能正常的45岁女性，在11个月的时间里，她有四次由水痘带状疱疹病毒(VZV)引起的神经系统疾病(脑膜脑炎、多灶性血管病、脊髓炎和炎症性脑干疾病)，所有患者都没有皮疹。脑脊液中含有抗VZV抗体，但不含VZV DNA，重申了检测脑脊液中抗VZV抗体在神经系统VZV感染诊断中的优越性。此外，在11个月期间检查的7个脑脊液样本中，有3个样本显示VZV诱导的以多形核细胞(PMN)为主的细胞增多，7个样本中有4个样本还含有增加的红细胞(RBC)。由于巨细胞病毒(CMV)引起的中枢和外周神经系统疾病患者脑脊液中PMN和RBC的升高也可发生，因此对脑脊液中PMN和RBC升高的慢性神经系统感染的鉴别诊断应包括对VZV和CMV的分析。
We describe an immunocompetent 45-year-old woman who had four episodes of neurological disease (meningoencephalitis, multifocal vasculopathy, myelitis and inflammatory brain stem disease) produced by varicella zoster virus (VZV) over an 11-month period, all in the absence of rash. The cerebrospinal fluid (CSF) contained anti-VZV IgG antibody, but not VZV DNA throughout her illness, reaffirming the superiority of detection of anti-VZV IgG in CSF compared to VZV DNA in diagnosing VZV infection of the nervous system. Moreover, 3 of 7 CSF samples examined during the 11 months showed a VZV-induced pleocytosis consisting predominantly of polymorphonuclear cells (PMNs), and 4 of 7 samples also contained increased numbers of red blood cells (RBCs). Because increased PMNs and RBCs in CSF can also occur in patients with central and peripheral nervous system disease produced by cytomegalovirus (CMV), the differential diagnosis of chronic nervous system infection with increased PMNs and RBCs in CSF should include analyses for both VZV and CMV.
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影响因子：
4.4
作者：
Gilden, Don;Nagel, Maria A.;Ransohoff, Richard M.;Cohrs, Randall J.;Mahalingam, Ravi;Tanabe, Jody L.
通讯作者：
Tanabe, Jody L.
影响因子：
9.9
作者：
CLIFFORD, DB;BULLER, RS;STORCH, GA
通讯作者：
STORCH, GA
影响因子：
11.2
作者：
TUCKER, T;DIX, RD;SCHMIDLEY, JW
通讯作者：
SCHMIDLEY, JW
影响因子：
14.5
作者：
DEVINSKY, O;CHO, ES;PRICE, RW
通讯作者：
PRICE, RW
影响因子：
158.5
作者：
FEIGIN, RD;SHACKELFORD, PG
通讯作者：
SHACKELFORD, PG